SERETIDE 250/MCG DISKUS INHALATION 60/DOSES

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Brand : SERETIDE

SERETIDE 250/MCG DISKUS INHALATION 60/DOSES

126.45

Sku : I-005883
Key features
SERETIDE 250/MCG DISKUS Inhalation 60/DOSES is an inhalation powder containing fluticasone propionate 250 µg and salmeterol 50 µg per dose. Fluticasone reduces airway inflammation via glucocorticoid receptor-mediated suppression of inflammatory gene transcription, while salmeterol selectively stimulates beta2-adrenergic receptors to increase intracellular cAMP and provide prolonged (~12-hour) bronchodilation. It is indicated for maintenance treatment of asthma where an inhaled corticosteroid/long-acting beta2-agonist combination is appropriate, and for maintenance treatment of COPD, including chronic bronchitis and emphysema, in appropriate patients. Supplied as a 60-dose Diskus inhalation powder, pack size 1 vial; prescription only.
- Brand: SERETIDE
- Active Ingredient: FLUTICASONE PROPIONATE 250µg, SALMETEROL 50µg
- Strength: 250,50µg
- Dosage Form: Inhalation powder
- Pack Size: 1 Vial
- Route: Inhalation use
- Prescription Status: Prescription
- Therapeutic Class: Respiratory
- Pharmacological Group: Adrenergics (Inhalants)
- Drug Class: Inhaled Corticosteroid (ICS) + Long-Acting Beta-2 Agonist (LABA) Combination
- Manufacturer: GLAXO OPERATION
- Country of Origin: United Kingdom
- SFDA Registration No.: 1411211314
- Shelf Life: 24 months
- Storage: store below 25°c
- Symptom Target: Asthma and COPD maintenance
- Sedating: No

Frequently bought together

Description

Specification

Indications

Approved Uses

Maintenance (regular) treatment of asthma where use of an inhaled corticosteroid/long-acting beta2-agonist combination is appropriate; and maintenance treatment of COPD (including chronic bronchitis and emphysema) in appropriate patients.

Dosage & Administration

Dosing by Condition

Asthma (adults and adolescents ≥12 years): 1 inhalation of 100/50µg, 250/50µg, or 500/50µg twice daily depending on severity. Asthma (children 4-11 years): 1 inhalation of 100/50µg twice daily. COPD (adults): 1 inhalation of 500/50µg twice daily

Initial Dose

1 inhalation (250/50µg) twice daily for moderate persistent asthma in adults

Maintenance Dose

1 inhalation twice daily (strength selected based on disease severity and response)

How to Take

Inhale 1 dose (250/50 micrograms) via Diskus twice daily about 12 hours apart. Open the Diskus, hold it level, slide the lever until it clicks to load a dose, breathe out gently away from the mouthpiece (do not exhale into the device), seal lips around the mouthpiece and inhale steadily and deeply, remove and hold breath ~10 seconds then breathe out slowly. Close the device. Rinse mouth/gargle with water and spit out after each dose.

Side Effects

Common Side Effects

Oropharyngeal candidiasis (thrush), dysphonia/hoarseness, throat irritation, headache, nasopharyngitis/upper respiratory tract infection; in COPD, increased risk of pneumonia; possible muscle cramps and palpitations/tremor.

Storage & Patient Advice

Patient Counseling

Use regularly twice daily (about 12 hours apart) even when well; not for sudden attacks-keep a fast-acting reliever inhaler; use correct Diskus technique (do not exhale into device, inhale steadily and deeply); rinse/gargle and spit after each use; seek review if symptoms worsen or reliever use increases; in COPD, report pneumonia symptoms (fever, increased cough/sputum, breathlessness); do not stop abruptly without clinician advice; keep device dry and store below 25°C.

Pharmacology

Mechanism of Action

Fluticasone propionate is an inhaled corticosteroid that reduces airway inflammation via glucocorticoid receptor-mediated suppression of inflammatory gene transcription; salmeterol is a long-acting selective beta2-agonist that relaxes bronchial smooth muscle by increasing intracellular cAMP, providing prolonged bronchodilation (~12 hours).