PIGMANORM 30GM CREAM

Dosage & Administration

Dosing by Condition

Melasma/facial hyperpigmentation: apply a thin layer once daily at night to affected areas; typical course up to 8 weeks, and do not continue long-term without clinician review.

Maximum Dose

Apply a thin film once daily (typically at night) to affected areas only; avoid large surface areas and prolonged continuous use-reassess if no response by ~8 weeks and generally limit continuous courses to about 8-12 weeks unless specialist-directed.

Dose Adjustment Notes

If irritation occurs, reduce frequency (e.g., every other night) and/or use moisturizer; avoid prolonged continuous use and reassess if no meaningful improvement by ~8 weeks or if significant adverse effects occur.

How to Take

Cleanse gently and dry the skin; apply a thin film to the hyperpigmented areas only once daily at night (preferably 30 minutes before bedtime). Avoid eyes, lips, and mucous membranes; wash hands after application. Use daily broad‑spectrum sunscreen and minimize sun exposure during treatment.

Side Effects

Common Side Effects

Application-site irritation: erythema/redness, burning/stinging, dryness, peeling/desquamation, pruritus/itching; increased photosensitivity.

Safety & Warnings

Contraindications

Hypersensitivity to hydroquinone, tretinoin, hydrocortisone, or any excipient; application to eyes/mucous membranes; use on broken, sunburned, windburned, or acutely inflamed/irritated skin. Avoid use in pregnancy unless clearly needed (generally not recommended) and avoid during breastfeeding on/near the breast. Do not use in children unless directed by a specialist.

Drug Interactions

Drug Interactions

Primarily topical/dermatologic interactions: avoid or use caution with other irritating/peeling agents (e.g., other retinoids, benzoyl peroxide, salicylic acid, AHAs, abrasive cleansers, alcohol/astringents) due to additive irritation; avoid concurrent benzoyl peroxide or other oxidizing agents at the same time of day as they can oxidize/inactivate hydroquinone (separate timing if needed).

Food Interaction

No clinically relevant food interactions (topical product).

Alcohol Interaction

Safe

Special Populations

Pregnancy

Contraindicated

Breastfeeding

Contraindicated

Elderly

Standard adult dosing; use with caution due to increased risk of skin atrophy with corticosteroid component

Kidney Impairment

No dose adjustment needed.

Storage & Patient Advice

Missed Dose

Apply when remembered that night; if it is close to the next scheduled application, skip the missed dose and resume the usual once-nightly schedule-do not double apply.

Monitoring Requirements

Monitor for local irritation/contact dermatitis, skin atrophy/telangiectasia (steroid effect), and exogenous ochronosis (rare, with prolonged hydroquinone use); if used over large areas/prolonged periods, consider risk of systemic corticosteroid effects (HPA-axis suppression) though uncommon with low-potency topical use.

Pharmacology

Mechanism of Action

Hydroquinone inhibits tyrosinase to reduce melanin synthesis; tretinoin increases epidermal turnover and enhances dispersion/penetration of pigment and hydroquinone; hydrocortisone reduces inflammation and irritation and may suppress inflammatory drivers of hyperpigmentation.

Product Information

Available Dosage Forms

Cream (topical).

Composition per Dose

Each 1g of cream contains: 40mg Hydroquinone (4%), 10mg Hydrocortisone (1%), and 1mg Tretinoin (0.1%).

Skin Condition

Hyperpigmentation, Melasma

Steroid Potency

Mild

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