ZORON 4/MG TAB 10/TAB

Indications

Approved Uses

Prevention and treatment of nausea and vomiting associated with cancer chemotherapy; prevention and treatment of nausea and vomiting associated with radiotherapy; prevention and treatment of postoperative nausea and vomiting (PONV).

Dosage & Administration

Dosing by Condition

Chemotherapy-induced nausea/vomiting (CINV): Oral regimens depend on emetogenicity and combination therapy; a common approach is 8 mg PO 30 minutes before chemotherapy, then 8 mg PO 8 hours later, then 8 mg PO every 12 hours for 1-2 days (longer in some protocols). For highly emetogenic chemotherapy, an oral 24 mg dose may be used as a single pre-chemotherapy dose (often as 3×8 mg) in combination with dexamethasone ± NK1 antagonist per guidelines.
Radiotherapy-induced nausea/vomiting (RINV): 8 mg PO 1-2 hours before radiotherapy, then 8 mg PO every 8 hours as needed/through the risk period per protocol.
Postoperative nausea/vomiting (PONV): Prophylaxis is typically 16 mg PO about 1 hour before induction of anesthesia (or 4 mg IV at induction in adults, per institutional protocol).

Initial Dose

8 mg orally 30 minutes before chemotherapy or 16 mg orally 1 hour before anesthesia

Maintenance Dose

8mg every 12 hours for 1-2 days following chemotherapy.

Maximum Dose

Oral: total daily dose generally should not exceed 32 mg; for highly emetogenic chemotherapy, a single 24 mg oral dose may be used (per regimen).

Children's Dosage

For chemotherapy-induced nausea and vomiting (ages 4-11): 4mg taken 30 minutes before chemotherapy, with subsequent 4mg doses at 4 and 8 hours after the first dose, then 4mg every 8 hours for 1-2 days. Approved for children 6 months and older for CINV.

How to Take

Swallow the 4 mg film‑coated tablet whole with water; may be taken with or without food. When used for prophylaxis, administer prior to the emetogenic trigger (e.g., before chemotherapy or radiotherapy; for PONV prophylaxis, give before induction of anesthesia as directed).

Safety & Warnings

Age Restriction

Approved for children 4 years and older for moderately emetogenic chemotherapy-induced nausea and vomiting; no routine use specified below 4 years.

Special Populations

Children

For chemotherapy-induced nausea and vomiting (ages 4-11): 4mg taken 30 minutes before chemotherapy, with subsequent 4mg doses at 4 and 8 hours after the first dose, then 4mg every 8 hours for 1-2 days. Approved for children 6 months and older for CINV.

Elderly

Dosage recommendation is the same as for the general population.

Kidney Impairment

No renal dose adjustment required.

Liver Impairment

Mild-moderate hepatic impairment: no adjustment; severe hepatic impairment: do not exceed a total daily dose of 8 mg.

Pharmacology

Half-Life

About 5.7 hours in normal adults; prolonged to 11.6 hours in mild-moderate hepatic impairment and up to 20 hours in severe hepatic impairment.

Product Information

Available Dosage Forms

Ondansetron is available (by product/market) as film‑coated tablets, orally disintegrating/orodispersible tablets, oral solution, and injection (IV/IM).

Composition per Dose

Each film-coated tablet: 4 mg ondansetron (as ondansetron hydrochloride dihydrate)

Generic Availability

Yes

Gi Condition

Nausea/Vomiting

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