GLYCELAX 2800/MG SUPP ADULT 12/SUPP

Indications

Approved Uses

Short-term relief of occasional constipation (to produce a bowel movement).

Dosage & Administration

Dosing by Condition

Occasional constipation (adults): 1 suppository (2800 mg) rectally once daily as needed.

Initial Dose

One 2800mg suppository rectally as a single dose.

Maintenance Dose

1 suppository rectally once daily as needed, not to exceed 7 consecutive days

Maximum Dose

1 adult suppository (2.8 g) rectally once in 24 hours.

Children's Dosage

Children under 6 years: use pediatric glycerin suppository (1000mg); Children 6-12 years: pediatric suppository; this adult 2800mg formulation is for adults and children over 12 years

Dose Adjustment Notes

No renal/hepatic dose adjustment is generally required due to minimal systemic absorption; use short-term only and do not use longer than 7 days unless directed by a clinician.

How to Take

For rectal use only. Remove the suppository from the blister/foil. If soft, chill briefly; you may moisten the tip with cool water to aid insertion. Lie on your side (often left side) with the upper knee bent, gently insert the pointed end fully into the rectum, then remain lying for ~10-15 minutes and try to retain until the urge to defecate occurs.

Side Effects

Common Side Effects

Rectal irritation or burning, mild abdominal/rectal cramping, and tenesmus (urge to defecate/feeling of incomplete evacuation).

Side Effect Frequency

Frequency not well-defined in labeling/references; reported adverse effects include rectal irritation/burning, abdominal cramping, tenesmus, and rarely rectal bleeding or hypersensitivity.

Safety & Warnings

Contraindications

Contraindicated/avoid use in: hypersensitivity to glycerin/excipients; intestinal obstruction/ileus; acute surgical abdomen (e.g., appendicitis) or undiagnosed abdominal pain with nausea/vomiting; and avoid use with significant rectal pathology such as active rectal bleeding (including bleeding hemorrhoids) or painful anal fissures unless medically advised.

Warnings & Precautions

For rectal use only; do not use if constipation is accompanied by abdominal pain, nausea, or vomiting; stop and seek medical advice if rectal bleeding occurs or if no bowel movement occurs after use; do not use for more than 7 days without medical advice and avoid frequent/prolonged use due to dependence risk.

Age Restriction

Adult 2.8 g glycerin suppository: intended for adults and adolescents ≥12 years; use in children <12 years only with a pediatric-strength product or on medical advice.

Driving Warning

Safe

Drug Interactions

Drug Interactions

No clinically significant systemic drug interactions expected; caution with concurrent frequent use of other laxatives due to additive diarrhea/dehydration/electrolyte disturbance risk.

Interaction Severity

No clinically significant drug interactions are expected; caution with concurrent laxatives due to additive effects if overused.

Food Interaction

No known clinically relevant food interactions (not applicable for rectal administration).

Alcohol Interaction

Safe

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Safe

Children

Children under 6 years: use pediatric glycerin suppository (1000mg); Children 6-12 years: pediatric suppository; this adult 2800mg formulation is for adults and children over 12 years

Elderly

Standard adult dosing; use with caution in elderly patients with hemorrhoids or rectal pathology

Kidney Impairment

No adjustment needed

Liver Impairment

No adjustment needed.

Storage & Patient Advice

Missed Dose

Used as needed; if you were going to use a dose and missed it, use when needed-do not double doses.

Stopping the Medicine

Safe to stop anytime; no tapering required

Overdose

Overuse may cause excessive bowel movements/diarrhea, abdominal cramping, and rectal irritation/bleeding; systemic toxicity is unlikely, but if accidentally swallowed or if severe/persistent symptoms occur, seek medical attention/poison center advice.

Patient Counseling

For rectal use only (do not swallow). Insert one adult suppository (2800 mg) as directed; expect a bowel movement in ~15-60 minutes. Use short-term only and do not use >7 days unless advised by a clinician. Stop and seek medical advice if severe abdominal pain, nausea/vomiting, rectal bleeding, or no bowel movement after use. Store below 30°C in original blister packaging.

Monitoring Requirements

No routine monitoring required for short-term use; monitor for rectal irritation or bleeding with repeated use

Pharmacology

Mechanism of Action

Hyperosmotic and local irritant effect in the rectum: draws water into the rectum to soften stool and increases rectal distension, stimulating peristalsis and evacuation.

Onset of Action

Typically 15-60 minutes after insertion (often ~15-30 minutes).

Duration of Effect

Intended to produce a single bowel movement; effect is not sustained beyond the immediate evacuation.

Half-Life

Not well-defined/unknown for rectal suppository use (systemic half-life not clinically relevant).

Bioavailability

Minimal systemic absorption; primarily local rectal action (osmotic/hyperosmotic effect).

Excretion

Primarily local effect with elimination in stool; any small absorbed fraction is metabolized and ultimately excreted renally as metabolites.

Protein Binding

Negligible/none expected.

Product Information

Available Dosage Forms

Suppository (rectal).

Composition per Dose

Each suppository: 2800mg glycerin

Generic Availability

Yes

OTC Alternatives

Bisacodyl suppositories; oral osmotic laxatives (polyethylene glycol/macrogol, lactulose); stimulant laxatives (senna); stool softener (docusate); rectal enemas (e.g., sodium phosphate) where appropriate.

Gi Condition

Constipation

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