FEXODINE 180/MG TAB 14/TAB

Indications

Approved Uses

Relief of symptoms of seasonal allergic rhinitis and chronic idiopathic urticaria.

Dosage & Administration

Dosing by Condition

Seasonal allergic rhinitis (adults and children ≥12 years): 180mg once daily. Chronic idiopathic urticaria (adults and children ≥12 years): 180mg once daily. Children 6-11 years: 30mg twice daily (using 30mg formulation)

Initial Dose

180mg once daily.

Maintenance Dose

180mg once daily.

Maximum Dose

180mg per day.

Children's Dosage

Children 6-11 years: 30mg twice daily. Children 2-5 years: 15mg twice daily (oral suspension). Not recommended under 2 years. The 180mg tablet is approved for children ≥12 years.

Dose Adjustment Notes

Renal impairment: start with 60 mg once daily (or equivalent reduced dosing) in decreased renal function; no hepatic dose adjustment is generally required.

How to Take

Swallow whole with water (oral use). May be taken with or without food; avoid taking with fruit juices (apple/orange/grapefruit). Separate from aluminum- or magnesium-containing antacids by at least 2 hours.

Side Effects

Common Side Effects

Headache, dizziness, nausea, fatigue; less commonly drowsiness/somnolence, dyspepsia, back pain, and upper respiratory tract infection symptoms.

Side Effect Frequency

Common (≥1%): headache, nausea, dizziness, somnolence/drowsiness; other reactions occur but are generally less frequent and vary by dataset/indication

Safety & Warnings

Contraindications

Hypersensitivity to fexofenadine hydrochloride or to any excipients.

Warnings & Precautions

Use with caution in renal impairment; avoid/space aluminum- or magnesium-containing antacids by ~2 hours; avoid taking with apple/orange/grapefruit juice (reduced absorption); discontinue and seek care if hypersensitivity occurs.

Age Restriction

180mg tablet: Not approved under 12 years

Driving Warning

No drowsiness warning; incidence of drowsiness similar to placebo

Drug Interactions

Drug Interactions

Aluminum- or magnesium-containing antacids (reduce absorption; separate by ~2 hours); erythromycin and ketoconazole (increase fexofenadine exposure); fruit juices (apple/orange/grapefruit) can reduce absorption-avoid or separate.

Interaction Severity

MODERATE: aluminum/magnesium-containing antacids (reduced absorption-separate by ≥2 hours). MODERATE: erythromycin or ketoconazole (increased fexofenadine exposure, usually without major clinical consequences). MODERATE: fruit juices (reduced absorption; avoid).

Food Interaction

Take with water; avoid fruit juices (apple, orange, grapefruit) because they can decrease absorption. Food does not require strict avoidance, but consistent administration is reasonable.

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Caution

Children

Children 6-11 years: 30mg twice daily. Children 2-5 years: 15mg twice daily (oral suspension). Not recommended under 2 years. The 180mg tablet is approved for children ≥12 years.

Elderly

Standard adult dosing, but dose adjustment may be necessary in patients with decreased renal function.

Kidney Impairment

Renal impairment: start with 60 mg once daily (especially when CrCl <80 mL/min); adjust based on response/tolerability.

Liver Impairment

No adjustment needed.

Storage & Patient Advice

Stopping the Medicine

Safe to stop anytime

Overdose

Symptoms may include dizziness, drowsiness, and dry mouth; management is supportive/symptomatic (consider decontamination if early), and hemodialysis is not effective-seek urgent medical advice.

Patient Counseling

Take 1 tablet (180 mg) once daily by mouth with water; avoid fruit juices. Do not take within 2 hours of aluminum/magnesium antacids. Usually non-drowsy, but if you feel dizzy/sleepy avoid driving. Seek care for severe reactions (e.g., swelling, trouble breathing) or if symptoms persist/worsen.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral H1-receptor antagonist that blocks histamine-mediated symptoms with minimal CNS penetration at usual doses.

Onset of Action

Approximately 1 hour (often within 1-2 hours).

Duration of Effect

24 hours.

Half-Life

11-15 hours (typically ~14 hours) in healthy adults

Bioavailability

Approximately 33%.

Metabolism

Minimal metabolism; ~5% metabolized, with the majority eliminated unchanged (primarily feces via biliary excretion and some urine)

Excretion

Primarily excreted unchanged in feces (~80%) and urine (~11%).

Protein Binding

~60-70%

Product Information

Available Dosage Forms

For this product (FEXODINE 180MG): film-coated tablet.

Composition per Dose

Each film-coated tablet: 180mg fexofenadine hydrochloride

Generic Availability

Yes

OTC Alternatives

Loratadine 10mg, cetirizine 10mg

Symptom Target

Allergy

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 10-08-2026