VERINE SR 200/MG CAP 30/CAP

Indications

Approved Uses

Symptomatic treatment of Irritable Bowel Syndrome (IBS), abdominal pain and cramps, persistent diarrhea, and flatulence associated with functional bowel disorders.

Dosage & Administration

Dosing by Condition

IBS/functional bowel spasm (adults): 200 mg modified-release capsule twice daily (morning and evening), preferably ~20 minutes before meals.

Initial Dose

One 200mg sustained-release capsule twice daily.

Maintenance Dose

One 200mg sustained-release capsule twice daily.

Maximum Dose

400mg per day (as two 200mg sustained-release capsules).

How to Take

Swallow the modified-release capsule whole with water; do not crush, chew, or open; take preferably about 20 minutes before meals (typically morning and evening).

Side Effects

Common Side Effects

Commonly reported: nausea and other mild GI upset; dizziness/headache; and hypersensitivity reactions such as rash/urticaria (rare but clinically important).

Side Effect Frequency

Most adverse effects are uncommon/rare and mainly hypersensitivity (e.g., rash, urticaria, angioedema, very rarely anaphylaxis); GI or CNS effects (e.g., nausea, constipation/diarrhea, headache, dizziness) are not consistently classified as common in standard labeling.

Drug Interactions

Drug Interactions

No clinically significant drug interactions are known/expected.

Interaction Severity

No clinically significant drug-drug interactions are well documented; routine interaction screening is still advised.

Storage & Patient Advice

Stopping the Medicine

May be stopped without tapering; typically discontinue when symptoms resolve or as directed by the prescriber.

Patient Counseling

Take 1 capsule (200 mg MR) twice daily, preferably ~20 minutes before meals; swallow whole with water (do not crush/chew/open). Seek urgent care for signs of allergy (rash, swelling, breathing difficulty). If symptoms persist/worsen after ~2 weeks or new alarm features occur (e.g., weight loss, bleeding), contact the prescriber.

Monitoring Requirements

No routine monitoring required. Liver function tests may be indicated if symptoms of hepatic sensitivity develop.

Pharmacology

Mechanism of Action

Direct musculotropic antispasmodic: relaxes GI smooth muscle (likely via effects on ion fluxes including calcium handling), relieving spasm with minimal effect on normal gut motility.

Onset of Action

Typically within about 1 hour (often cited range ~20-60 minutes).

Duration of Effect

Approximately 12 hours per dose for the 200 mg modified-release capsule (supports twice-daily dosing).

Half-Life

Approximately 2 hours (reported for the main circulating metabolite[s] after oral dosing; parent mebeverine has a very short/undetectable half-life due to rapid hydrolysis).

Bioavailability

Mebeverine is absorbed after oral administration and undergoes extensive first-pass metabolism to inactive metabolites; parent drug systemic levels are low, and elimination is mainly via urine as metabolites.

Product Information

Available Dosage Forms

For this SFDA-registered product: modified-release capsule (oral). Other mebeverine products may exist as immediate-release tablets (e.g., 135 mg) in some markets; oral suspension is not a standard/established mebeverine dosage form.

Composition per Dose

Each sustained-release capsule: 200mg mebeverine hydrochloride

Generic Availability

Yes

Gi Condition

IBS

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