SELEKTINE 15/MG TAB 30/TAB

Indications

Approved Uses

Osteoarthritis and rheumatoid arthritis (adults).

Dosage & Administration

Dosing by Condition

Osteoarthritis: 7.5 mg PO once daily, may increase to 15 mg once daily; Rheumatoid arthritis: 7.5 mg PO once daily, may increase to 15 mg once daily; maximum 15 mg/day.

Initial Dose

7.5 mg once daily

Maintenance Dose

7.5mg to 15mg once daily

Maximum Dose

15 mg per day

Dose Adjustment Notes

Use the lowest effective dose for the shortest duration; in hemodialysis, maximum 7.5 mg/day; avoid/use not recommended in severe renal impairment (especially non-dialysis) and use caution in elderly and in hepatic impairment.

How to Take

Swallow the tablet whole with water; may be taken with or without food (take with food/milk if GI upset occurs); take once daily at the same time each day; do not exceed 15 mg/day.

Side Effects

Common Side Effects

Dyspepsia, abdominal pain, nausea, diarrhea, headache, dizziness, peripheral edema; rash can occur.

Side Effect Frequency

Common (≥1% to <10%): dyspepsia, nausea, abdominal pain, diarrhea, constipation, flatulence, headache, dizziness, rash/pruritus, peripheral edema, hypertension, anemia, and upper respiratory tract infection. Uncommon (≥0.1% to <1%): GI ulceration or GI bleeding, elevated liver enzymes, and renal function impairment (including acute kidney injury).

Safety & Warnings

Contraindications

Contraindicated in: hypersensitivity to meloxicam; history of asthma/urticaria/other allergic-type reactions after aspirin or other NSAIDs (AERD); and for peri-operative pain in CABG surgery; additionally avoid/contraindicate in active GI bleeding/peptic ulcer and in late pregnancy (3rd trimester).

Warnings & Precautions

Key warnings/precautions: increased risk of CV thrombotic events; increased risk of serious GI bleeding/ulceration/perforation; avoid use in CABG peri-operative setting; use caution in elderly and in patients with prior ulcer/GI bleed, cardiovascular disease, hypertension, renal impairment, heart failure, dehydration; monitor renal function and blood pressure; may cause serious skin reactions and hypersensitivity; may mask fever/inflammation.

Age Restriction

Not recommended for pediatric use; this 15 mg tablet strength is intended for adults (generally ≥18 years).

Drug Interactions

Interaction Severity

MAJOR: anticoagulants (e.g., warfarin/DOACs) and antiplatelets (increased bleeding), other NSAIDs (additive GI/renal toxicity), high-risk combinations affecting renal perfusion (ACEi/ARB + diuretic, especially with dehydration). MODERATE: lithium (increased levels), methotrexate (increased toxicity), cyclosporine/tacrolimus (nephrotoxicity), SSRIs/SNRIs (increased GI bleeding).

Food Interaction

Take with food

Special Populations

Elderly

Start at 7.5 mg once daily; use lowest effective dose; monitor renal function, blood pressure, and GI symptoms closely

Kidney Impairment

Mild to moderate renal impairment: no adjustment; severe renal impairment: avoid/not recommended; hemodialysis: maximum 7.5 mg/day.

Liver Impairment

Mild to moderate hepatic impairment: no dosage adjustment; severe hepatic impairment: use is not recommended/avoid (insufficient data and higher risk).

Storage & Patient Advice

Missed Dose

Take as soon as remembered; skip if near the time of the next dose; do not double the dose

Stopping the Medicine

Safe to stop anytime; no tapering required for short-term use

Overdose

Symptoms: GI upset (nausea/vomiting/epigastric pain), drowsiness/lethargy, GI bleeding; severe cases may include hypertension, acute kidney injury, respiratory depression, coma. Management: supportive care, consider activated charcoal if early; cholestyramine can enhance elimination; urgent medical evaluation required.

Patient Counseling

Take SELEKTINE (meloxicam) 15 mg by mouth once daily as prescribed; take with food or milk and use the lowest effective dose for the shortest duration. Do not exceed 15 mg/day and avoid taking other NSAIDs (e.g., ibuprofen, diclofenac, naproxen) or aspirin for pain unless your prescriber advises. Seek urgent care for signs of GI bleeding/ulcer (severe stomach pain, black/tarry stools, vomiting blood), allergic reaction (wheeze, facial swelling, rash), or serious cardiovascular symptoms (chest pain, shortness of breath, sudden weakness/slurred speech). Limit alcohol (increases GI bleeding risk) and inform your clinician if you have a history of ulcers/bleeding, kidney disease, heart failure/hypertension, or if you are pregnant/trying to conceive (avoid especially in the 3rd trimester).

Monitoring Requirements

Monitor blood pressure and signs/symptoms of GI bleeding; check renal function (SCr/eGFR) at baseline and periodically in at-risk or long-term use; consider CBC and liver enzymes with prolonged therapy or if clinically indicated.

Pharmacology

Mechanism of Action

Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis; preferentially inhibits COX-2 over COX-1 at lower therapeutic doses.

Duration of Effect

Approximately 24 hours.

Half-Life

15 to 20 hours

Bioavailability

89%

Metabolism

Hepatic metabolism primarily via CYP2C9, with a minor contribution from CYP3A4, producing inactive metabolites.

Protein Binding

>99% protein bound (mainly to albumin).

Product Information

Available Dosage Forms

Tablet (this product). Other meloxicam dosage forms that may exist in some markets include oral suspension and injection; IV solution and capsule are not standard meloxicam forms.

Composition per Dose

Each tablet: 15 mg meloxicam

OTC Alternatives

Ibuprofen (OTC where available); naproxen may be OTC in some countries but is prescription-only in others.

Pain Type

Joint/Muscular

Nsaid

Yes

Opioid

No

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