RINOFED EXPECTORANT SYRUP 100ML

Indications

Approved Uses

Symptomatic relief of cough with chest congestion (productive cough) and associated upper respiratory symptoms such as nasal congestion, rhinorrhea, and sneezing due to the common cold and allergic rhinitis (including hay fever).

Dosage & Administration

Dosing by Condition

For cough with chest congestion and nasal/allergic symptoms (oral syrup): Adults and ≥12 years: 10 mL every 4-6 hours as needed (max 4 doses/24 h). Children 6-12 years: 5 mL every 4-6 hours (max 4 doses/24 h). Children 2-6 years: 2.5 mL every 4-6 hours (max 4 doses/24 h). Do not use in children <2 years unless directed by a clinician.

Dose Adjustment Notes

No routine dose adjustment is defined, but use caution in older adults (greater sensitivity to sedation/anticholinergic and sympathomimetic effects) and in moderate-severe renal impairment (pseudoephedrine is primarily renally eliminated); use caution in hepatic impairment due to triprolidine metabolism.

How to Take

Shake well before use. Measure doses with a calibrated oral syringe/medicine spoon/cup (do not estimate). May be taken with or without food; take with food if stomach upset occurs. Do not exceed the recommended dose or frequency.

Side Effects

Common Side Effects

Drowsiness/sedation, dizziness, dry mouth/throat/nose, nausea/GI upset, headache, nervousness or insomnia, blurred vision, palpitations/tachycardia, and urinary hesitancy/retention (especially in men with BPH).

Side Effect Frequency

Frequency is not reliably quantifiable for this exact fixed-dose OTC combination across labels; counsel that common effects include drowsiness/sedation and dry mouth/throat/nose, with less common effects including dizziness, nausea, headache, nervousness/insomnia, blurred vision, palpitations/tachycardia, and urinary retention.

Safety & Warnings

Contraindications

Hypersensitivity to ingredients; concomitant use of MAO inhibitors or within 14 days of stopping; severe hypertension; severe coronary artery disease; narrow-angle glaucoma; urinary retention/prostatic hypertrophy; hyperthyroidism; children <2 years.

Warnings & Precautions

Use with caution in hypertension, ischemic heart disease/arrhythmias, diabetes, hyperthyroidism, glaucoma/increased intraocular pressure, prostatic hypertrophy/urinary retention, and renal impairment; may cause drowsiness/dizziness-avoid driving/operating machinery; avoid alcohol/CNS depressants; avoid other products containing decongestants/antihistamines; do not exceed recommended dose and avoid near bedtime if insomnia occurs.

Age Restriction

Do not use in children <2 years; for children 2-<12 years use only on doctor’s advice; routine OTC dosing from ≥12 years.

Driving Warning

Avoid Driving

Drug Interactions

Drug Interactions

MAO inhibitors (contraindicated-hypertensive crisis); other sympathomimetics/decongestants (additive CV/CNS effects); tricyclic antidepressants (potentiate sympathomimetic effects); antihypertensives including beta‑blockers/methyldopa (reduced antihypertensive effect/possible BP rise); alcohol and other CNS depressants/sedatives (additive sedation with triprolidine).

Interaction Severity

MAJOR/Contraindicated: MAO inhibitors (and within 14 days of stopping) due to risk of hypertensive crisis with pseudoephedrine. MODERATE: Other CNS depressants (including alcohol) may increase sedation (triprolidine); tricyclic antidepressants and other sympathomimetics can potentiate pressor/CNS effects; antihypertensives may have reduced effect. Use caution with beta‑blockers and other agents affecting BP/HR. MINOR: Other anticholinergic/antihistamine drugs may increase anticholinergic effects.

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Elderly

Start at lower end of dose range; elderly patients are more susceptible to anticholinergic effects of triprolidine (confusion, urinary retention, constipation) and cardiovascular effects of pseudoephedrine. Monitor closely.

Kidney Impairment

No specific dose adjustment established; use with caution in moderate-severe renal impairment and consider dose reduction/extended interval in severe renal impairment.

Liver Impairment

No specific dose adjustment established; use with caution in hepatic impairment (especially severe).

Storage & Patient Advice

Missed Dose

Take as soon as remembered; skip if near the time of the next dose. Do not double the dose.

Stopping the Medicine

Safe to stop anytime; this is a symptomatic treatment with no dependence or withdrawal effects.

Overdose

Symptoms: CNS depression or stimulation (drowsiness, agitation, hallucinations, seizures), tachycardia/arrhythmias, hypertension (or hypotension), anticholinergic effects (dry mouth, mydriasis), urinary retention; Management: stop drug, urgent medical evaluation/poison center, supportive care (airway/ventilation, cardiac/BP monitoring), consider activated charcoal if early and appropriate.

Patient Counseling

Measure doses accurately and do not exceed the maximum daily dosing. May cause drowsiness and blurred vision-avoid driving/operating machinery until effects are known; avoid alcohol and other sedatives. Do not use with (or within 14 days of) MAOIs. Check other cold/cough/allergy products to avoid duplicate pseudoephedrine/antihistamines. Seek medical advice before use if you have hypertension/heart disease, hyperthyroidism, glaucoma, diabetes, or difficulty urinating/BPH; stop and seek care for severe palpitations, chest pain, or allergic reaction. If symptoms persist >7 days, worsen, or are accompanied by high fever, consult a clinician. Store below 25°C.

Monitoring Requirements

No routine monitoring required in healthy individuals. Monitor blood pressure in hypertensive patients.

Pharmacology

Mechanism of Action

Guaifenesin increases hydration of respiratory secretions and reduces mucus viscosity to aid expectoration. Pseudoephedrine is a sympathomimetic that stimulates adrenergic receptors (predominantly alpha effects) causing vasoconstriction in nasal mucosa to reduce congestion. Triprolidine is a first‑generation H1 receptor antagonist with anticholinergic and sedative properties that reduces histamine‑mediated symptoms (sneezing, rhinorrhea).

Onset of Action

Typically within ~15-30 minutes for symptom relief after an oral immediate‑release dose (with peak effects often around 1-2 hours).

Duration of Effect

4-6 hours

Bioavailability

Guaifenesin: well absorbed orally (absolute bioavailability not consistently defined). Pseudoephedrine: high oral bioavailability (commonly reported ~90% or higher). Triprolidine: well absorbed orally; absolute bioavailability not consistently defined.

Metabolism

Guaifenesin: rapidly metabolized (primarily hepatic) to inactive metabolites and excreted in urine. Pseudoephedrine: minimal hepatic metabolism; largely excreted unchanged in urine (renal clearance affected by urinary pH). Triprolidine: hepatic metabolism (CYP involvement reported, including CYP2D6) with renal excretion of metabolites.

Excretion

Guaifenesin: Renal (as metabolites). Pseudoephedrine: Renal (primarily as unchanged drug). Triprolidine: Renal (primarily as metabolites).

Protein Binding

Guaifenesin: Unknown; Pseudoephedrine: ~20%; Triprolidine: ~Unknown

Product Information

Available Dosage Forms

Syrup

Composition per Dose

Each 5 ml: Guaifenesin 100 mg + Pseudoephedrine hydrochloride 30 mg + Triprolidine hydrochloride 1.25 mg

OTC Alternatives

Depending on symptoms: (1) Expectorant only: guaifenesin single‑ingredient syrup/tablets. (2) Decongestant: pseudoephedrine (where available) or topical nasal decongestants for short courses. (3) Antihistamine: non‑sedating options such as loratadine or cetirizine for allergic symptoms. (4) Combination cold products only if avoiding duplicate ingredients.

Symptom Target

Cough, Congestion, Runny Nose, Allergy, Multi-symptom

Sedating

Yes

Legal Disclaimer - Al Mujtama Pharmacy

The product information provided is derived from verified pharmaceutical references and is intended for general health education only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Al Mujtama Pharmacy assumes no legal or medical liability for:

• Any therapeutic decision made based on the information displayed without consulting a licensed physician or pharmacist
• Any discrepancy between the information provided and the product's package insert or SFDA guidelines
• Any misuse of medication resulting from personal interpretation of the content displayed

Important notice: Drug formulations and instructions may vary between production batches. Always rely on the leaflet included inside the product packaging you have, and consult your pharmacist or physician before starting, adjusting, or discontinuing any medication.

By using this content, you acknowledge that you have read this disclaimer and agree that Al Mujtama Pharmacy bears no liability arising from reliance on this information as a substitute for direct medical consultation.

Your health is a trust - always consult your doctor first.