OPTICIN EYE DROPS 5ML

Indications

Approved Uses

Bacterial conjunctivitis and bacterial corneal ulcer/keratitis caused by susceptible organisms.

Dosage & Administration

Dosing by Condition

Bacterial Conjunctivitis: 1-2 drops every 2 hours while awake for 2 days, then 1-2 drops every 4 hours while awake for the next 5 days. Corneal Ulcers: Day 1: 2 drops every 15 minutes for the first 6 hours, then 2 drops every 30 minutes for the remainder of the day. Day 2: 2 drops hourly. Days 3-14: 2 drops every 4 hours.

Initial Dose

Conjunctivitis: 1-2 drops every 2 hours while awake; Corneal ulcer: 2 drops every 15 minutes for first 6 hours

Maintenance Dose

Conjunctivitis: 1-2 drops every 4 hours while awake; Corneal ulcer: 2 drops every 4 hours

Maximum Dose

No fixed maximum daily drop count is defined; for corneal ulcer, intensive initial dosing may be 2 drops every 15 minutes for the first 6 hours then every 30 minutes for the remainder of day 1 (then tapered per response/prescriber)

Children's Dosage

Bacterial conjunctivitis: approved for children ≥1 year - same dosing as adults. Corneal ulcers: approved for children ≥1 year - same dosing as adults

Dose Adjustment Notes

No renal or hepatic dose adjustment is required for ophthalmic use because systemic exposure is minimal; use usual dosing unless otherwise directed by an ophthalmologist.

How to Take

Wash hands. Tilt head back, pull down lower eyelid to form a pocket, instill the prescribed number of drops into the conjunctival sac without touching the dropper tip to the eye/skin/surfaces. Close the eye gently and apply nasolacrimal occlusion (press inner corner) for 1-2 minutes to reduce systemic absorption. If using other ophthalmic products, separate by at least 5 minutes (ointments last).

Side Effects

Common Side Effects

Local burning/stinging or discomfort, foreign body sensation, conjunctival hyperemia/redness, itching, lid margin crusting, unpleasant/bitter taste; white crystalline corneal precipitate can occur especially in corneal ulcer patients.

Side Effect Frequency

Common (1-10%): ocular burning/discomfort, foreign body sensation/irritation, conjunctival hyperemia/redness, unpleasant/bitter taste; Uncommon (<1%): white crystalline precipitate/deposits (notably in corneal ulcer patients), lid margin crusting, keratopathy/corneal staining, photophobia, decreased visual acuity/blurred vision, tearing, hypersensitivity reactions.

Safety & Warnings

Contraindications

Hypersensitivity to ciprofloxacin, other quinolone/fluoroquinolone antibiotics, or any component of the formulation

Warnings & Precautions

For ophthalmic use only (not for injection or oral use); avoid contaminating dropper tip; discontinue if hypersensitivity occurs; prolonged use may cause overgrowth of non-susceptible organisms including fungi; contact lens precautions (remove lenses; generally avoid lenses during active infection and wait ~15 minutes before reinsertion if permitted); white crystalline precipitate may occur in corneal ulcer patients and is usually benign

Age Restriction

No age restriction for eye drops; appropriate studies have not demonstrated pediatric-specific problems that limit usefulness in children.

Drug Interactions

Drug Interactions

Clinically significant systemic drug interactions are unlikely due to low systemic absorption; if using other ophthalmic products, separate administrations by at least 5 minutes

Interaction Severity

No clinically significant systemic drug interactions expected; practical interaction is dilution/washout with other topical eye medications-separate administration by at least 5 minutes (ointments last).

Food Interaction

No clinically relevant food interactions (ophthalmic route).

Alcohol Interaction

Safe

Special Populations

Breastfeeding

Caution

Children

Bacterial conjunctivitis: approved for children ≥1 year - same dosing as adults. Corneal ulcers: approved for children ≥1 year - same dosing as adults

Elderly

Standard adult dosing. Use with caution in patients also taking corticosteroids due to an increased risk of tendon inflammation.

Kidney Impairment

No dose adjustment needed

Liver Impairment

No dose adjustment needed

Storage & Patient Advice

Missed Dose

Instill the missed dose as soon as remembered; if it is close to the next scheduled dose, skip the missed dose and resume the regular schedule-do not double doses.

Stopping the Medicine

Complete the prescribed course even if symptoms improve; no taper is required

Patient Counseling

Use exactly as prescribed and complete the course. Wash hands; avoid touching the dropper tip. Remove contact lenses during active infection and before dosing; reinsert only when symptoms resolve and at least 15 minutes after a dose if advised. Expect mild transient stinging/blurred vision; avoid driving until vision clears. Space other eye meds by ≥5 minutes (ointments last). Seek urgent care for severe pain, photophobia, vision changes, swelling, or rash/allergy. Store below 30°C per SFDA; discard after the in-use period stated in the leaflet (commonly 4 weeks after opening if specified).

Monitoring Requirements

Monitor clinical response (symptom improvement, discharge/redness, visual symptoms); if no improvement or worsening within 48-72 hours (or sooner for severe pain/vision change), reassess and consider culture/sensitivity and ophthalmology review.

Pharmacology

Mechanism of Action

Fluoroquinolone bactericidal activity via inhibition of bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, blocking DNA replication and transcription.

Onset of Action

Within minutes after instillation (antibacterial activity begins promptly).

Duration of Effect

Several hours (typically ~4-6 hours), hence repeated dosing is needed to maintain therapeutic levels.

Half-Life

Systemic elimination half-life of ciprofloxacin is approximately 4 hours in adults with normal renal function; an 'ocular half-life' is not a standard labeled PK parameter for ciprofloxacin eye drops and is not reliably defined for routine clinical use.

Metabolism

Ciprofloxacin undergoes limited hepatic metabolism to several metabolites, but after ophthalmic administration systemic absorption is minimal and metabolism is typically not clinically relevant.

Product Information

Available Dosage Forms

Eye drops solution, ophthalmic ointment

Composition per Dose

Each mL: Ciprofloxacin hydrochloride equivalent to 3 mg ciprofloxacin (0.3%)

Generic Availability

Yes

OTC Alternatives

No OTC alternative for prescription ophthalmic antibiotic; lubricating eye drops available OTC for symptomatic relief only

Target Organ

Eye

Preservative Free

No

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