ONE ALPHA 1MCG CAP

Benefits & Uses

Primary Benefit

Supports calcium and phosphate absorption, bone mineralization, and management of metabolic bone diseases in patients with renal or hepatic impairment

Health Claims

Treatment and prevention of renal osteodystrophy; management of hypoparathyroidism; treatment of nutritional and malabsorptive rickets and osteomalacia; supports calcium and phosphate homeostasis

Common Deficiency Symptoms

Bone pain, osteomalacia, rickets, muscle weakness, hypocalcemia, tetany, secondary hyperparathyroidism, renal osteodystrophy

Target Population

Patients with chronic kidney disease, hypoparathyroidism, osteomalacia, rickets, osteoporosis, and conditions requiring active vitamin D supplementation due to impaired renal hydroxylation

Scientific Evidence Level

Strong

Usage & Dosage

Suggested Use

Take 1 capsule orally once daily, or as directed by a physician

Serving Size

1 capsule

Servings Per Container

100

Recommended Daily Intake

Dose is individualized by a physician based on patient's condition and biochemical response; typical adult maintenance dose is 0.25-1mcg daily.

Upper Tolerable Limit

No established UL for alfacalcidol specifically; doses above 1 mcg/day require medical monitoring due to hypercalcemia risk; UL for native Vitamin D3 is 4000 IU/day (100 mcg) for adults

Side Effects

Possible Side Effects

Hypercalcemia (nausea, vomiting, constipation, weakness, polyuria, polydipsia), hypercalciuria, soft tissue calcification, headache, pruritus; symptoms resolve upon dose reduction

Toxicity Risk

High

Upper Tolerable Limit

No established UL for alfacalcidol specifically; doses above 1 mcg/day require medical monitoring due to hypercalcemia risk; UL for native Vitamin D3 is 4000 IU/day (100 mcg) for adults

Safety & Warnings

Contraindications

Hypercalcemia, hypervitaminosis D (vitamin D toxicity), and hypersensitivity to alfacalcidol or any excipient

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Caution

Children Suitability

Suitable for children under medical supervision; pediatric dosing (neonates and children) is individualized by physician based on weight and condition

Interactions

Medication Interactions

Thiazide diuretics increase hypercalcemia risk; cardiac glycosides (digoxin) toxicity enhanced by hypercalcemia; antacids containing magnesium may cause hypermagnesemia; phenytoin and barbiturates may reduce efficacy; corticosteroids antagonize effects

Supplement Interactions

Calcium supplements increase hypercalcemia risk - monitor serum calcium; vitamin D supplements (cholecalciferol/ergocalciferol) may cause additive toxicity; magnesium supplements require monitoring in renal patients

Synergistic Nutrients

Calcium (for bone mineralization); magnesium (cofactor for vitamin D metabolism); vitamin K2 (directs calcium to bone and away from soft tissues)

Special Populations

Target Population

Patients with chronic kidney disease, hypoparathyroidism, osteomalacia, rickets, osteoporosis, and conditions requiring active vitamin D supplementation due to impaired renal hydroxylation

Children Suitability

Suitable for children under medical supervision; pediatric dosing (neonates and children) is individualized by physician based on weight and condition

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Caution

Storage & Patient Advice

SFDA Storage Conditions

store below 25°c

Patient Counseling

Take exactly as prescribed; do not change the dose yourself. You will need regular monitoring of serum calcium and phosphate (and renal function as clinically indicated). Report symptoms of hypercalcemia promptly (e.g., nausea/vomiting, constipation, weakness, confusion, excessive thirst and urination). Do not take additional vitamin D or calcium supplements (or calcium-containing antacids) unless your prescriber instructs you.

Science & Evidence

Bioavailability Form

Alfacalcidol (1α-hydroxyvitamin D3) - a synthetic prodrug that requires only hepatic 25-hydroxylation to become active calcitriol, bypassing renal activation; superior to cholecalciferol in patients with renal failure

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Strong

Food Sources

Alfacalcidol is a synthetic compound not found in food; natural vitamin D precursors found in fatty fish (salmon, mackerel), egg yolks, liver, and UV-exposed mushrooms

Product Information

Supplement Type

Vitamin

Allergen Info

Capsule shell may contain gelatin (animal-derived); free from gluten and soy; consult product leaflet for full excipient list

Certification

SFDA registered (Registration No. 10-5444-24); manufactured by Leo Pharma, Denmark under GMP standards

Vitamin D Form

Alfacalcidol (1α-hydroxyvitamin D3) - active vitamin D analog, not D2 or D3

Calcium Included

No

Vitamin K Included

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 06-05-2026