LORADAY SYRUP

Indications

Approved Uses

Symptomatic treatment of allergic rhinitis (seasonal/perennial) and chronic idiopathic urticaria.

Dosage & Administration

Dosing by Condition

Allergic rhinitis or urticaria: Adults and children ≥12 years: 10 mg once daily (10 mL of 1 mg/mL syrup). Children 2-11 years: if >30 kg, 10 mg once daily (10 mL); if ≤30 kg, 5 mg once daily (5 mL).

Initial Dose

10mg once daily for adults and children 6 years and older.

Maintenance Dose

10mg once daily for adults and children 6 years and older; 5mg once daily for children 2-5 years.

Maximum Dose

10mg per day for adults and children 6 years and older; 5mg per day for children 2-5 years.

Children's Dosage

Children 2-5 years: 5mg (5ml) once daily. Children 6 years and older: 10mg (10ml) once daily. Not recommended under 2 years. Weight-based dosing (>30kg vs ≤30kg) is not specified in authoritative sources reviewed.

Dose Adjustment Notes

In severe hepatic impairment or severe renal impairment (e.g., CrCl/GFR <30 mL/min), use a lower initial dose or extend the dosing interval (commonly 10 mg every other day in adults).

How to Take

Shake well before use; measure the dose with an oral syringe/medicine spoon; may be taken with or without food; administer once daily as directed.

Side Effects

Common Side Effects

Headache, fatigue, dry mouth; somnolence/drowsiness can occur but is generally uncommon at recommended doses.

Safety & Warnings

Contraindications

Hypersensitivity to loratadine or any excipients

Age Restriction

Not recommended for children under 2 years of age.

Drug Interactions

Drug Interactions

CYP3A4/CYP2D6 inhibitors (e.g., ketoconazole, erythromycin, cimetidine) can increase loratadine/desloratadine exposure; clinically significant effects are uncommon at recommended doses.

Food Interaction

No restriction.

Special Populations

Children

Children 2-5 years: 5mg (5ml) once daily. Children 6 years and older: 10mg (10ml) once daily. Not recommended under 2 years. Weight-based dosing (>30kg vs ≤30kg) is not specified in authoritative sources reviewed.

Kidney Impairment

Severe renal impairment (GFR/CrCl <30 mL/min): adults and children ≥6 years or >30 kg: 10 mg every other day; children 2-5 years: 5 mg every other day.

Storage & Patient Advice

Missed Dose

Take the missed dose when remembered; if it is close to the next dose, skip the missed dose and resume the regular schedule; do not double doses.

Patient Counseling

Shake well and measure doses accurately; take once daily and do not exceed the recommended dose; may be taken with or without food; drowsiness is uncommon but if it occurs avoid driving/alcohol; seek medical advice if symptoms persist/worsen; store below 25°C and keep out of reach of children.

Monitoring Requirements

Patients require monitoring for symptomatic relief, sedation, and potential anticholinergic effects. Renal and hepatic function should be closely monitored in patients with kidney or liver impairment. Cardiac function should be observed in individuals with history of cardiac arrhythmias.

Pharmacology

Mechanism of Action

Selective peripheral histamine H1-receptor antagonist (often described as an inverse agonist) that reduces histamine-mediated allergic symptoms with minimal CNS penetration at usual doses.

Onset of Action

1-3 hours.

Duration of Effect

Approximately 24 hours (supports once-daily dosing).

Half-Life

Loratadine: ~8-12 hours; active metabolite (desloratadine/descarboethoxyloratadine): ~17-24 hours (often cited around ~27 hours in some references).

Bioavailability

Oral bioavailability is not ~100%; loratadine undergoes significant first-pass metabolism and has incomplete systemic availability (commonly cited as ~40% or described as variable).

Excretion

Approximately 40% in urine and ~42% in feces, primarily as metabolites (over ~10 days).

Protein Binding

97-99%.

Product Information

Available Dosage Forms

For this product (LORADAY): Syrup (oral).

Composition per Dose

Each 5ml: Loratadine 5mg (1mg/ml)

Generic Availability

Yes

OTC Alternatives

Other OTC second-generation antihistamines: cetirizine, levocetirizine, fexofenadine; (first-generation option: chlorpheniramine, more sedating).

Symptom Target

Allergy, Runny Nose

Sedating

No

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