ESSENTIAL D-3 50000 IU 12CAP

Benefits & Uses

Primary Benefit

Corrects and prevents vitamin D deficiency, supporting bone health, immune function, and calcium absorption

Health Claims

Supports bone mineralization and maintenance; promotes calcium and phosphorus absorption; supports immune system function; reduces risk of rickets and osteomalacia; contributes to normal muscle function

Common Deficiency Symptoms

Fatigue, bone pain, muscle weakness, frequent infections, depression, hair loss, impaired wound healing, rickets in children, osteomalacia in adults

Target Population

Adults with confirmed vitamin D deficiency or insufficiency, individuals with limited sun exposure, elderly adults, obese individuals, patients with malabsorption syndromes, dark-skinned individuals, postmenopausal women

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels rise within 1-2 weeks of supplementation; clinical symptom improvement in 4-8 weeks; bone density improvements after 3-6 months of sustained therapy

Usage & Dosage

Suggested Use

Take 1 capsule as directed by a physician, typically once weekly or as prescribed, with a fat-containing meal

Serving Size

1 capsule

Servings Per Container

12

Best Time to Take

With meals

Recommended Daily Intake

Adults: 600-800 IU/day (15-20 mcg); therapeutic dosing for deficiency: up to 50,000 IU weekly under medical supervision

Upper Tolerable Limit

4,000 IU/day (100 mcg) for general adults; therapeutic doses above this require medical supervision and serum monitoring

Absorption Enhancers

Fat-containing meals (olive oil, avocado, nuts); magnesium (required for vitamin D metabolism); bile acids facilitate intestinal absorption

Absorption Inhibitors

Orlistat (fat absorption blocker reduces vitamin D absorption); cholestyramine and colestipol (bile acid sequestrants); mineral oil laxatives; high-dose calcium supplements taken simultaneously

Side Effects

Possible Side Effects

At excessive doses: hypercalcemia, nausea, vomiting, constipation, polyuria, polydipsia, weakness, confusion, nephrocalcinosis, and cardiac arrhythmias; generally well-tolerated at prescribed therapeutic doses

Toxicity Risk

Medium

Upper Tolerable Limit

4,000 IU/day (100 mcg) for general adults; therapeutic doses above this require medical supervision and serum monitoring

Safety & Warnings

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Children Suitability

Not recommended for children without medical supervision; 50,000 IU is a high therapeutic dose intended for adults under physician direction

Interactions

Medication Interactions

Thiazide diuretics increase hypercalcemia risk; corticosteroids reduce vitamin D efficacy; anticonvulsants (phenytoin, phenobarbital) accelerate vitamin D catabolism; rifampin reduces serum vitamin D levels; digoxin toxicity risk increases with hypercalcemia induced by excess vitamin D

Special Populations

Target Population

Adults with confirmed vitamin D deficiency or insufficiency, individuals with limited sun exposure, elderly adults, obese individuals, patients with malabsorption syndromes, dark-skinned individuals, postmenopausal women

Children Suitability

Not recommended for children without medical supervision; 50,000 IU is a high therapeutic dose intended for adults under physician direction

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

store below 30°c

Storage Conditions

Store below 30°C in a cool, dry place. Keep away from direct sunlight and moisture. Keep out of reach of children

Patient Counseling

High-dose cholecalciferol (vitamin D3) 50,000 IU oral capsule (prescription): take only as prescribed (commonly once weekly or per clinician plan for deficiency), not as a daily supplement. Take with/after a meal containing fat to improve absorption. Do not exceed the prescribed dose or combine with other high-dose vitamin D/calcium products unless advised; toxicity can cause hypercalcemia (e.g., nausea/vomiting, constipation, polyuria/polydipsia, confusion) and kidney injury. Monitoring of serum 25‑OH vitamin D and calcium (± renal function/phosphate) is recommended during high-dose therapy, especially with prolonged use or risk factors. Check for interactions/precautions: thiazide diuretics (↑ hypercalcemia risk), digoxin (arrhythmia risk if hypercalcemia), and conditions like hypercalcemia, nephrolithiasis, severe renal impairment, sarcoidosis/other granulomatous disease. Store below 30°C and keep out of reach of children.

Science & Evidence

Bioavailability Form

Vitamin D3 (cholecalciferol) - the most bioavailable form, approximately 87% more effective than D2 (ergocalciferol) at raising and sustaining serum 25(OH)D levels

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels rise within 1-2 weeks of supplementation; clinical symptom improvement in 4-8 weeks; bone density improvements after 3-6 months of sustained therapy

Food Sources

Fatty fish (salmon, mackerel, sardines), cod liver oil, egg yolks, beef liver, UV-exposed mushrooms, fortified milk and dairy products, fortified cereals

Product Information

Supplement Type

Vitamin

Certification

SFDA registered (Registration No. 410222686); GMP manufactured by Arnet Pharmaceutical Corp, USA

Suitable for Vegetarians

Yes

Suitable for Vegans

No

Vitamin D Form

D3

Calcium Included

No

Vitamin K Included

No