DUSPATALIN RETARD 200/MG 30/CAP

Indications

Approved Uses

Symptomatic treatment of irritable bowel syndrome (IBS) and associated symptoms such as abdominal pain/cramps, bowel habit disturbance and intestinal spasm; may also be used for gastrointestinal spasm secondary to organic disease where clinically appropriate.

Dosage & Administration

Dosing by Condition

IBS / gastrointestinal spasm (adults): 200 mg modified-release capsule twice daily (morning and evening), preferably ~20 minutes before meals.

Initial Dose

One 200mg prolonged-release capsule twice daily.

Maintenance Dose

One 200mg prolonged-release capsule twice daily.

Maximum Dose

400mg per day

How to Take

Swallow the modified-release capsule whole with water; do not crush, chew, or open. Take preferably about 20 minutes before meals (typically morning and evening).

Side Effects

Common Side Effects

Generally uncommon; most reported are hypersensitivity reactions (rash, urticaria, angioedema) and occasionally dizziness or headache; gastrointestinal effects such as nausea/constipation may occur but are not prominent.

Side Effect Frequency

Most reported adverse effects are hypersensitivity reactions (e.g., rash, urticaria, angioedema/face oedema) and are uncommon/rare; gastrointestinal or CNS effects (e.g., nausea, constipation, headache, dizziness) may occur but are not consistently listed as common with defined frequencies across labels.

Safety & Warnings

Contraindications

Hypersensitivity to mebeverine hydrochloride or to any excipients.

Driving Warning

Safe

Drug Interactions

Drug Interactions

No clinically significant drug interactions are known/expected; avoid duplicative use with other antispasmodics/IBS symptom-relief medicines unless advised by a clinician.

Interaction Severity

No clinically significant drug interactions are known/expected.

Special Populations

Elderly

Standard adult dosing.

Storage & Patient Advice

Patient Counseling

Take 1 modified‑release capsule (200 mg) twice daily, about 20 minutes before meals (typically before breakfast and before the evening meal). Swallow whole with water; do not crush or chew. If a dose is missed, skip it and take the next dose at the usual time (do not double). Seek urgent care for signs of hypersensitivity (rash, urticaria, facial/throat swelling, breathing difficulty). Store below 30°C.

Pharmacology

Mechanism of Action

Musculotropic antispasmodic that directly relaxes gastrointestinal smooth muscle, relieving spasm without significantly affecting normal motility; proposed mechanisms include effects on ion channels (e.g., sodium/calcium) but the exact mechanism is not fully established.

Onset of Action

About 1 hour (roughly 30-60 minutes) for symptom relief, recognizing individual variability.

Duration of Effect

Approximately 12 hours per dose for the 200 mg modified-/prolonged-release capsule (supports twice-daily dosing).

Half-Life

For the modified‑release capsule, the effective elimination half‑life reported for the main circulating metabolite (DMAC) is approximately 5-6 hours; the parent compound is rapidly metabolized and does not have a clinically meaningful half‑life.

Bioavailability

Oral bioavailability of the parent drug is low/limited because mebeverine undergoes extensive first‑pass metabolism; systemic exposure is mainly to metabolites (some sources describe high relative bioavailability of the MR formulation vs immediate‑release, but not high absolute parent bioavailability).

Protein Binding

Protein binding is not well-established/commonly specified in major labeling for mebeverine MR (treat as unknown/undocumented for clinical decision-making).

Product Information

Available Dosage Forms

For Duspatalin/mebeverine products: immediate-release tablets (commonly 135 mg) and modified-/prolonged-release capsules (200 mg).

Composition per Dose

Each prolonged-release capsule: 200mg mebeverine hydrochloride

Generic Availability

Yes

Gi Condition

IBS

Legal Disclaimer - Al Mujtama Pharmacy

The product information provided is derived from verified pharmaceutical references and is intended for general health education only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Al Mujtama Pharmacy assumes no legal or medical liability for:

• Any therapeutic decision made based on the information displayed without consulting a licensed physician or pharmacist
• Any discrepancy between the information provided and the product's package insert or SFDA guidelines
• Any misuse of medication resulting from personal interpretation of the content displayed

Important notice: Drug formulations and instructions may vary between production batches. Always rely on the leaflet included inside the product packaging you have, and consult your pharmacist or physician before starting, adjusting, or discontinuing any medication.

By using this content, you acknowledge that you have read this disclaimer and agree that Al Mujtama Pharmacy bears no liability arising from reliance on this information as a substitute for direct medical consultation.

Your health is a trust - always consult your doctor first.