DESLIN 0.5/MG/ML SYRUP 150ML

Indications

Approved Uses

Seasonal Allergic Rhinitis, Perennial Allergic Rhinitis, Chronic Idiopathic Urticaria.

Dosage & Administration

Dosing by Condition

Allergic rhinitis and chronic idiopathic urticaria: Adults/adolescents ≥12 years: 5 mg once daily (10 mL of 0.5 mg/mL). Children 6-11 years: 2.5 mg once daily (5 mL). Children 1-5 years: 1.25 mg once daily (2.5 mL). Children 6-11 months: 1 mg once daily (2 mL) where locally approved/labelled.

Initial Dose

Adults and adolescents ≥12 years: 5 mg (10 ml) once daily

Maintenance Dose

Adults and adolescents ≥12 years: 5 mg (10 ml) once daily

Maximum Dose

5 mg once daily; no additional benefit observed at higher doses.

Children's Dosage

6-11 months: 1 mg once daily. 1-5 years: 1.25 mg once daily. 6-11 years: 2.5 mg once daily. ≥12 years: 5 mg once daily.

How to Take

Oral use: measure the dose with an accurate measuring device (oral syringe/cup); may be taken with or without food; administer once daily. If the product is an oral solution, routine 'shake well' is not required (shake only if the label instructs).

Side Effects

Common Side Effects

Common: headache, dry mouth, fatigue; may also include pharyngitis/sore throat, nausea, and somnolence/drowsiness (generally low incidence).

Side Effect Frequency

In adults/adolescents: headache, dry mouth, and fatigue are generally reported as common (≈1-10%) and often near placebo rates in trials; hypersensitivity reactions, tachycardia/palpitations, seizures, and elevated liver enzymes are rare/very rare and mainly post-marketing.

Safety & Warnings

Contraindications

Hypersensitivity to desloratadine, loratadine, or any component (excipients) of the formulation.

Warnings & Precautions

Use with caution in severe renal impairment and severe hepatic impairment; consider seizure history (especially in young children) as antihistamines have been associated with rare seizure reports; counsel on hypersensitivity risk.

Age Restriction

Approved for children ≥6 months (and adults), with age-based dosing.

Driving Warning

Does not cause drowsiness

Drug Interactions

Drug Interactions

Plasma concentrations may be increased by ketoconazole, erythromycin, azithromycin, fluoxetine, and cimetidine; clinically significant effects are generally not expected.

Interaction Severity

Clinically relevant interactions are generally limited: strong CYP/P-gp inhibitors (e.g., ketoconazole, erythromycin, azithromycin, fluoxetine, cimetidine) can increase desloratadine exposure but usually without major clinical consequence; caution with alcohol/CNS depressants if sedation occurs.

Food Interaction

No clinically significant food interaction; can be taken with or without food.

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

6-11 months: 1 mg once daily. 1-5 years: 1.25 mg once daily. 6-11 years: 2.5 mg once daily. ≥12 years: 5 mg once daily.

Elderly

Standard adult dosing, but caution is advised, and a lower starting dose may be considered due to potential for decreased renal, hepatic, or cardiac function.

Liver Impairment

Severe hepatic impairment: start 5 mg every other day (or equivalent age-appropriate reduced frequency for pediatrics).

Storage & Patient Advice

Missed Dose

Take as soon as remembered; skip if near the time of the next dose; do not double the dose

Stopping the Medicine

Safe to stop anytime.

Overdose

Seek urgent medical advice; management is symptomatic/supportive (consider activated charcoal if appropriate); somnolence and tachycardia can occur; desloratadine is not effectively removed by hemodialysis.

Patient Counseling

Use an accurate measuring device; take once daily and do not exceed the recommended dose; may be taken with or without food; drowsiness is uncommon but possible-use caution with driving and avoid alcohol if sedated; store below 30°C; seek medical advice if symptoms persist/worsen or for very young children per local labeling.

Monitoring Requirements

No routine monitoring required, but baseline renal and liver function tests may be considered.

Pharmacology

Mechanism of Action

Selective peripheral H1-receptor antagonist that blocks histamine-mediated allergic symptoms; minimal anticholinergic activity and generally limited CNS penetration compared with first-generation antihistamines.

Onset of Action

Within 1 hour.

Duration of Effect

24 hours.

Bioavailability

Absolute bioavailability is not routinely stated as a single definitive percentage in many references; clinically, desloratadine is well absorbed after oral administration (solution and tablet considered comparable at equivalent doses).

Metabolism

Hepatic metabolism to active 3-hydroxydesloratadine followed by glucuronidation; the specific CYP enzymes responsible are not definitively identified in established labeling.

Excretion

Elimination occurs via both urine and feces (roughly comparable contributions; exact percentages vary by source/study).

Product Information

Available Dosage Forms

For this SFDA-registered product: Oral solution (2.5 mg/5 mL) in a 150 mL bottle; other desloratadine dosage forms (e.g., tablets/ODT) may exist as separate products but are not part of this specific listing.

Composition per Dose

Each 5ml of oral solution: 2.5mg desloratadine

Generic Availability

Yes

OTC Alternatives

OTC alternatives for allergic rhinitis/urticaria symptoms include loratadine, cetirizine, levocetirizine, and fexofenadine (choose age-appropriate formulations such as syrups for children).

Symptom Target

Allergy, Runny Nose

Sedating

No

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