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Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
ATOZET 10/10MG 30TAB
- Sku : I-026914
Key features
ATOZET 10/10 mg film-coated tablet is a film-coated tablet containing atorvastatin calcium 10 mg and ezetimibe 10 mg. Atorvastatin inhibits HMG-CoA reductase to reduce hepatic cholesterol synthesis and upregulate LDL receptors, while ezetimibe blocks the NPC1L1 transporter in the small intestine to decrease dietary and biliary cholesterol absorption. It is indicated for the treatment of primary hypercholesterolemia and mixed dyslipidemia to lower elevated LDL cholesterol. Available by prescription as film-coated tablets in a pack of 30 tablets.- Brand: ATOZET
- Active Ingredient: ATORVASTATIN CALCIUM 10mg, EZETIMIBE 10mg
- Strength: 10,10mg
- Dosage Form: Film-coated tablet
- Pack Size: 30 Tablets
- Route: Oral use
- Prescription Status: Prescription
- Therapeutic Class: Lipid Modifying
- Pharmacological Group: Lipid Modifying Agents
- Drug Class: HMG-CoA Reductase Inhibitor (Statin) + Cholesterol Absorption Inhibitor combination
- Manufacturer: MSD International GmbH (PUERTO RICO Branch)
- Country of Origin: United States
- SFDA Registration No.: 22-262-10
- Shelf Life: 24 months
- Storage: store below 30°c
- Lipid Target: Both: Triglycerides & LDL
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Vitamins & Supplements > Omega-3 Supplements
Dosage & Administration
Initial Dose
Atorvastatin 10 mg / Ezetimibe 10 mg once daily
Special Populations
Pregnancy
Contraindicated
Breastfeeding
Contraindicated
Pharmacology
Mechanism of Action
Atorvastatin inhibits HMG-CoA reductase to reduce hepatic cholesterol synthesis and upregulate LDL receptors; ezetimibe inhibits NPC1L1 in the small intestine to reduce dietary/biliary cholesterol absorption.
Onset of Action
LDL-C lowering is typically evident within ~1-2 weeks, with near-maximal effect by ~4 weeks.
Metabolism
Atorvastatin: extensive hepatic metabolism primarily via CYP3A4 to active ortho- and para-hydroxylated metabolites. Ezetimibe: rapidly metabolized in the intestine and liver by glucuronidation to active ezetimibe‑glucuronide with enterohepatic recirculation.
Protein Binding
Atorvastatin: ≥98%; Ezetimibe: >90%
Product Information
Available Dosage Forms
Film-coated tablet.
Composition per Dose
Each film-coated tablet: 10mg ezetimibe, 10mg atorvastatin (as atorvastatin calcium trihydrate).
Lipid Target
Both
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