ACC LONG 600/MG EFF TAB BLACKBERRY FLAVOR 10/TAB

Indications

Approved Uses

Mucolytic treatment of respiratory tract conditions associated with excessive/viscous mucus (e.g., acute/chronic bronchitis and COPD) to facilitate expectoration.

Off-Label Uses

Paracetamol (acetaminophen) overdose antidote (primarily IV or oral NAC protocols); prevention of contrast-associated acute kidney injury (evidence mixed; not routinely recommended in many guidelines).

Dosage & Administration

Dosing by Condition

Adults and adolescents ≥14 years: 600 mg orally once daily (this product). Children typically require lower-dose formulations (e.g., 200 mg) per age/weight and local labeling.

Initial Dose

600mg twice daily (one effervescent tablet twice daily dissolved in water)

Maintenance Dose

600 mg twice daily.

Maximum Dose

1200 mg per day (600 mg twice daily) for this ACC LONG 600 mg formulation.

Dose Adjustment Notes

No routine dose adjustment is required in renal or hepatic impairment for mucolytic use; use caution in severe hepatic disease and in patients with a history of peptic ulcer or asthma.

How to Prepare

Dissolve 1 effervescent tablet completely in a glass of water and drink the solution immediately after dissolution.

Side Effects

Common Side Effects

Common: nausea, vomiting, diarrhea, abdominal discomfort/heartburn; less common: stomatitis, headache, rash/urticaria.

Side Effect Frequency

Common (1-10%): gastrointestinal upset (e.g., nausea, vomiting, diarrhea/abdominal discomfort) and hypersensitivity-type skin reactions (e.g., rash/urticaria); anaphylactoid reactions are primarily associated with IV acetylcysteine and are not 'very common' for oral use.

Safety & Warnings

Contraindications

Hypersensitivity to acetylcysteine or any excipients; active peptic ulcer disease is not an absolute contraindication but warrants caution; phenylketonuria is relevant only if the effervescent tablet contains aspartame (phenylalanine source).

Warnings & Precautions

Use with caution in asthma/bronchospasm risk; caution with history of peptic ulcer disease/GI irritation; discontinue and seek care if hypersensitivity occurs; consider excipient-related cautions (e.g., PKU if aspartame present, and other sugar-intolerance syndromes depending on formulation).

Drug Interactions

Food Interaction

No clinically significant food interaction; may be taken with or without food (after meals may reduce GI upset).

Special Populations

Elderly

Standard adult dosing

Kidney Impairment

No adjustment needed

Liver Impairment

No routine dose adjustment is required; use with caution in severe hepatic impairment.

Storage & Patient Advice

Preparation Instructions

Dissolve 1 effervescent tablet completely in a glass of water and drink the solution immediately after dissolution.

Stopping the Medicine

Safe to stop anytime; no tapering required

Overdose

Oral overdose is usually mild; symptoms may include nausea, vomiting, diarrhea, and abdominal pain; management is supportive/symptomatic, with medical evaluation if significant ingestion or symptoms occur.

Monitoring Requirements

No routine monitoring required for standard mucolytic use

Pharmacology

Mechanism of Action

Mucolytic by cleaving disulfide bonds in mucoproteins to reduce mucus viscosity; also replenishes intracellular glutathione via cysteine donation, providing antioxidant effects.

Duration of Effect

Not well-defined for oral mucolytic effect; clinical benefit is assessed over days of therapy rather than a predictable hourly duration per dose.

Bioavailability

Oral bioavailability is low, approximately 6-10% due to significant first-pass metabolism.

Metabolism

Extensive first-pass metabolism in the intestinal wall and liver; rapidly deacetylated to cysteine and further converted to disulfides and glutathione-related metabolites.

Product Information

Available Dosage Forms

Effervescent tablet, granules for oral solution, solution for inhalation, injectable solution.

Composition per Dose

Each effervescent tablet: 600mg acetylcysteine

Generic Availability

Yes

Symptom Target

Cough

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 13-05-2026