VOMINORE TAB 20/TAB

Indications

Approved Uses

Prevention and treatment of nausea, vomiting, and dizziness associated with motion sickness; symptomatic treatment of vertigo due to vestibular disorders (e.g., Ménière’s disease/labyrinthine disorders).

Off-Label Uses

Nausea and vomiting of pregnancy (when used under clinician guidance); postoperative nausea and vomiting (adjunct/alternative in some settings).

Dosage & Administration

Dosing by Condition

Motion sickness: 25-50 mg meclozine (i.e., 1-2 tablets) taken about 1 hour before travel; may repeat every 24 hours if needed. Vertigo (vestibular): 25-100 mg meclozine/day (i.e., 1-4 tablets/day) in divided doses as directed.

Initial Dose

1 tablet at bedtime or 1 hour before travel

Maintenance Dose

1 tablet once or twice daily as needed

Maximum Dose

For motion sickness: 50 mg per 24 hours. For vertigo: 100 mg per 24 hours.

Dose Adjustment Notes

No specific renal or hepatic dose-adjustment recommendations are established; use caution in elderly patients and in hepatic/renal impairment due to potential increased sensitivity/accumulation and anticholinergic/CNS effects.

How to Take

Swallow tablet whole with water; may be taken with or without food. For motion sickness, take the dose about 1 hour before travel.

Side Effects

Common Side Effects

Drowsiness, dry mouth, blurred vision, fatigue, headache, constipation

Side Effect Frequency

Common: drowsiness/sedation, dry mouth, fatigue; Less common/rare: blurred vision, constipation, urinary retention, tachycardia/palpitations, paradoxical CNS excitation; Hypersensitivity reactions (including anaphylaxis) are rare.

Safety & Warnings

Contraindications

Hypersensitivity to meclozine, pyridoxine, or any excipients

Warnings & Precautions

May cause drowsiness-avoid driving/operating machinery; avoid alcohol/other sedatives; use caution in narrow-angle glaucoma, prostatic hypertrophy/urinary retention/bladder-neck obstruction, asthma/COPD, epilepsy/seizure disorders, hepatic impairment, and in older adults (greater anticholinergic/CNS effects)

Driving Warning

May Cause Drowsiness

Drug Interactions

Drug Interactions

CNS depressants (including alcohol), other anticholinergic drugs; MAO inhibitors (may enhance/prolong anticholinergic/CNS effects); levodopa (pyridoxine can reduce levodopa effect if not combined with a decarboxylase inhibitor)

Interaction Severity

MAJOR: MAO inhibitors (may prolong/intensify anticholinergic/CNS effects). MODERATE: Alcohol and other CNS depressants (additive sedation/impairment); other anticholinergic drugs (additive anticholinergic effects).

Food Interaction

No restriction

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Caution

Liver Impairment

No specific dose adjustment established; use with caution in hepatic impairment (especially severe)

Storage & Patient Advice

Stopping the Medicine

Safe to stop anytime

Overdose

Symptoms: marked drowsiness/sedation, anticholinergic toxicity (dry mouth, mydriasis/blurred vision, tachycardia, urinary retention), agitation/hallucinations, seizures (especially in children), possible coma/respiratory depression; Management: urgent medical evaluation, supportive care, consider activated charcoal if early, treat seizures/agitation as needed

Patient Counseling

May cause drowsiness/dizziness-avoid driving or operating machinery until effects are known; avoid alcohol and other sedatives. Swallow with water; can take with or without food. For motion sickness, take 1 hour before travel and do not exceed the labeled daily maximum (commonly 50 mg meclozine/24 h unless directed otherwise). Use caution/seek advice if you have glaucoma, urinary retention/prostatic enlargement, or are elderly.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Meclozine: H1-receptor antagonism with central anticholinergic effects that reduces vestibular stimulation and depresses labyrinthine/vestibular pathways to the vomiting center, producing antiemetic and antivertigo effects. Pyridoxine: vitamin B6 cofactor; may contribute to antiemetic benefit (notably in nausea of pregnancy) though the exact antiemetic mechanism is not fully defined.

Onset of Action

About 1 hour (roughly 30-60 minutes).

Duration of Effect

Approximately 12-24 hours.

Half-Life

Meclozine: ~5-6 hours (reported range varies by source); Pyridoxine: no single clinically used plasma half‑life for the tablet-body stores/functional half‑life of pyridoxal phosphate is prolonged (often cited ~15-20 days).

Bioavailability

Meclozine: oral absorption occurs but absolute bioavailability is not well defined in labeling; Pyridoxine: well absorbed orally (commonly cited ~75% or higher, dose-dependent).

Metabolism

Meclozine: hepatic metabolism (CYP involvement not reliably defined for routine labeling); Pyridoxine: hepatic conversion to active coenzyme forms (pyridoxal phosphate/pyridoxamine phosphate) with further metabolism to 4‑pyridoxic acid.

Product Information

Available Dosage Forms

Tablet.

Composition per Dose

Each tablet: Meclozine 25mg + Pyridoxine (Vitamin B6) 50mg

Generic Availability

Yes

OTC Alternatives

Dimenhydrinate; diphenhydramine (both OTC options for motion sickness in many markets).

Gi Condition

Nausea/Vomiting

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