PASSIFLORE PROMOTION OF SLEEP CAP 45/CAP

Benefits & Uses

Primary Benefit

Promotes relaxation and supports natural sleep onset through GABAergic and anxiolytic mechanisms of Passiflora incarnata extract.

Health Claims

Supports relaxation and promotes natural sleep; helps reduce mild anxiety and nervous tension; traditional herbal remedy for insomnia and restlessness

Common Deficiency Symptoms

Not applicable - Passiflora incarnata is not an essential nutrient; target symptoms include insomnia, anxiety, restlessness, and nervous tension

Target Population

Adults experiencing occasional insomnia, difficulty falling asleep, mild anxiety, or nervous restlessness

Scientific Evidence Level

Moderate

Usage & Dosage

Suggested Use

Take 1 to 2 tablets 30-60 minutes before bedtime with a glass of water

Serving Size

1 tablet (300mg)

Servings Per Container

45

Best Time to Take

Before bed

Recommended Daily Intake

Typical clinical doses range from 200-800 mg per day of Passiflora incarnata extract

Upper Tolerable Limit

No established UL; doses up to 800mg/day have been used in clinical studies without significant adverse effects

Side Effects

Possible Side Effects

Generally well-tolerated at recommended doses; possible effects include daytime drowsiness, dizziness, and mild gastrointestinal discomfort; rare cases of hypersensitivity reported

Toxicity Risk

Low

Upper Tolerable Limit

No established UL; doses up to 800mg/day have been used in clinical studies without significant adverse effects

Safety & Warnings

Contraindications

Hypersensitivity to Passiflora incarnata (or any excipients); pregnancy; breastfeeding; discontinue/avoid use at least 2 weeks before surgery or procedures requiring anesthesia/sedation.

Pregnancy Safety

Avoid

Breastfeeding Safety

Avoid

Interactions

Medication Interactions

May potentiate CNS depressants including benzodiazepines, barbiturates, opioids, and sedative antihistamines; may interact with MAO inhibitors; may enhance anticoagulant effects of warfarin

Supplement Interactions

Additive sedative effects with valerian, hops, lemon balm, kava, and melatonin; use with caution in combination

Synergistic Nutrients

Valerian root (Valeriana officinalis), lemon balm (Melissa officinalis), magnesium glycinate, and melatonin for enhanced sleep support

Special Populations

Target Population

Adults experiencing occasional insomnia, difficulty falling asleep, mild anxiety, or nervous restlessness

Pregnancy Safety

Avoid

Breastfeeding Safety

Avoid

Storage & Patient Advice

SFDA Storage Conditions

store below 25°c

Patient Counseling

Take orally as directed; for sleep support, take the dose about 30-60 minutes before bedtime. May cause drowsiness-avoid driving/operating machinery after taking it. Avoid alcohol and other CNS depressants/sedatives (e.g., benzodiazepines, opioids, sedating antihistamines) unless advised by a clinician. Consult a healthcare professional before use if pregnant or breastfeeding, or if taking other medicines/you have a medical condition; seek medical advice if insomnia persists or worsens.

Science & Evidence

Scientific Evidence Level

Moderate

Food Sources

Passiflora incarnata is not a common dietary food source; passion fruit (Passiflora edulis) is a related species consumed as food but differs in phytochemical profile

Product Information

Supplement Type

Herbal

Certification

SFDA registered (Registration No. 2310222773); manufactured under GMP by Arko Pharma, France

Active Mechanism

GABA modulator - flavonoids (particularly chrysin and flavone glycosides) in Passiflora incarnata bind to GABA-A receptors, enhancing inhibitory neurotransmission to reduce neuronal excitability, promote anxiolysis, and facilitate sleep onset

Habit Forming

Low risk

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 12-07-2026