OTRIVIN 0.1% NASAL SP MENTHOL 10ML

Indications

Approved Uses

Temporary relief of nasal congestion associated with common cold, sinusitis, and allergic rhinitis/hay fever (upper respiratory allergies).

Dosage & Administration

Dosing by Condition

Nasal congestion: Adults and children ≥6 years (0.1%): 1 spray or 2-3 drops in each nostril up to 2-3 times daily (about every 8-10 hours); do not exceed 3 applications in 24 hours; use for ≤5-7 days.

Dose Adjustment Notes

Use the age-appropriate strength: 0.05% for younger children (commonly 2-6 years) and 0.1% for adults and older children (commonly ≥6 years); limit continuous use to no more than 5-7 days to avoid rebound congestion.

Side Effects

Common Side Effects

Transient nasal burning/stinging, nasal dryness/irritation, sneezing; headache can occur; rebound congestion (rhinitis medicamentosa) with prolonged or excessive use.

Safety & Warnings

Contraindications

Hypersensitivity to xylometazoline/excipients; atrophic rhinitis/rhinitis sicca; acute angle-closure glaucoma; after transsphenoidal hypophysectomy or surgery exposing the dura mater; concomitant use of MAO inhibitors or within 14 days of stopping them.

Warnings & Precautions

Do not use >5-7 days (risk of rebound congestion); use caution in hypertension/cardiovascular disease, hyperthyroidism, diabetes, pheochromocytoma, and prostatic hypertrophy; avoid concomitant sympathomimetics; avoid eye contact and do not share the applicator.

Drug Interactions

Drug Interactions

MAO inhibitors (contraindicated during and within 14 days of use); tricyclic/tetracyclic antidepressants (may potentiate pressor/sympathomimetic effects); other sympathomimetics (additive cardiovascular effects).

Special Populations

Elderly

Use cautiously in elderly patients with cardiac disease, diabetes mellitus, or poorly controlled hypertension.

Storage & Patient Advice

Stopping the Medicine

Do not use longer than 5-7 consecutive days; stop when no longer needed and discontinue if rebound congestion occurs (support with saline/other non-decongestant measures).

Overdose

Overdose (especially in children) may cause CNS depression (drowsiness/sedation), bradycardia, hypotension, hypothermia, respiratory depression/coma, or paradoxical hypertension/tachycardia; seek urgent medical care if swallowed or excessive dosing occurs-treatment is supportive/symptomatic.

Patient Counseling

Use the correct strength for age (0.1% generally for ≥6 years/adults; avoid in younger children unless specifically labeled). Do not use more than 2-3 times/day (max 3 doses/24 h) and do not use longer than 5-7 days to prevent rebound congestion. Seek medical advice if symptoms persist/worsen or if significant cardiovascular disease, hypertension, hyperthyroidism, diabetes, glaucoma, or prostate enlargement; avoid use with MAOIs within 14 days. Do not share the bottle; clean the nozzle after use.

Pharmacology

Mechanism of Action

Alpha-adrenergic agonist (primarily alpha-1) producing vasoconstriction of nasal mucosal vessels, reducing edema and nasal congestion.

Bioavailability

Minimal systemic absorption with recommended intranasal use; systemic exposure can increase with excessive dosing, prolonged use, or if swallowed (especially in children).

Excretion

Not well characterized for intranasal xylometazoline; any absorbed drug is expected to be metabolized and eliminated primarily via renal excretion of metabolites, but definitive human data are limited.

Product Information

Available Dosage Forms

Nasal drops, solution (this SFDA-registered product); Otrivin also exists in some markets as a nasal spray solution, but that is a separate presentation/registration.

Composition per Dose

Each 1 ml nasal spray: xylometazoline hydrochloride 1 mg (0.1%); with menthol as excipient

Symptom Target

Congestion

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 11-08-2026