NEORIN 5/MG 20/FC TAB

Indications

Approved Uses

Relief of symptoms of seasonal and perennial allergic rhinitis (nasal and non-nasal) and chronic idiopathic urticaria (pruritus and hives).

Dosage & Administration

Dosing by Condition

Allergic rhinitis (seasonal and perennial): Adults and adolescents ≥12 years: 5mg once daily. Chronic idiopathic urticaria: Adults and adolescents ≥12 years: 5mg once daily

Initial Dose

5 mg once daily.

Maintenance Dose

5 mg once daily.

Maximum Dose

5 mg per day.

Children's Dosage

Tablet form not recommended under 12 years

How to Take

Swallow tablet whole with water; may be taken with or without food; take once daily as directed.

Side Effects

Common Side Effects

Headache, dry mouth, fatigue, somnolence/drowsiness (uncommon), pharyngitis; nausea and myalgia can occur.

Safety & Warnings

Contraindications

Hypersensitivity to desloratadine, loratadine, or any excipients in the formulation.

Warnings & Precautions

Use with caution in severe renal impairment; use with caution in hepatic impairment; caution in patients with a history of seizures (seizures have been reported, particularly in pediatric patients); counsel to stop and seek care for hypersensitivity reactions.

Age Restriction

NEORIN 5 mg film‑coated tablet: indicated for adults and adolescents ≥12 years; not recommended for children <12 years (use pediatric oral solution/syrup formulations for younger ages where available).

Driving Warning

Unlikely to cause drowsiness

Drug Interactions

Drug Interactions

Clinically relevant interactions are limited; increased desloratadine exposure has been reported with strong CYP/P-gp inhibitors such as ketoconazole, erythromycin, azithromycin, fluoxetine, and cimetidine, but usually without clinically significant effects; advise caution with alcohol/CNS depressants if sedation occurs.

Interaction Severity

MINOR: ketoconazole, erythromycin, azithromycin, cimetidine, fluoxetine (may increase desloratadine exposure without clinically meaningful effects in most patients); MINOR: alcohol/CNS depressants (possible additive sedation in susceptible individuals).

Food Interaction

No restriction.

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

Tablet form not recommended under 12 years

Liver Impairment

Severe hepatic impairment: 5 mg every other day (or consider alternative/close monitoring).

Storage & Patient Advice

Missed Dose

Take as soon as remembered; skip if near next dose. Do not double the dose.

Stopping the Medicine

Safe to stop anytime

Overdose

Overdose: provide symptomatic and supportive care; consider decontamination (e.g., activated charcoal) if recent ingestion; somnolence is common and tachycardia/headache may occur; desloratadine is not expected to be removed by hemodialysis; seek urgent medical attention/poison center advice.

Patient Counseling

Take 1 tablet (5 mg) once daily with or without food; may cause drowsiness in some-use caution with driving until you know your response; avoid alcohol/CNS depressants if drowsy; do not exceed the dose; seek advice if pregnant/breastfeeding or if you have kidney/liver disease (may need every-other-day dosing); store below 25°C and consult a clinician if symptoms persist/worsen.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral histamine H1-receptor antagonist that blocks histamine-mediated allergic symptoms with minimal anticholinergic and CNS effects.

Onset of Action

Within 1 hour.

Duration of Effect

24 hours.

Half-Life

Approximately 27 hours (desloratadine).

Bioavailability

Orally absorbed; food has no clinically significant effect on exposure; absolute bioavailability is not well established in labeling.

Metabolism

Hepatic metabolism to the active metabolite 3-hydroxydesloratadine followed by glucuronidation; the specific CYP isoenzymes are not definitively established (CYP3A4/2C8 may contribute), and desloratadine is not a clinically significant CYP inhibitor.

Excretion

Eliminated via both urine and feces, largely as metabolites; only a small fraction is excreted unchanged.

Protein Binding

82-87%.

Product Information

Available Dosage Forms

For NEORIN specifically: Film-coated tablet (oral).

Composition per Dose

Each film-coated tablet: 5mg desloratadine

Generic Availability

Yes

OTC Alternatives

Loratadine, cetirizine, fexofenadine (OTC antihistamine alternatives).

Symptom Target

Allergy, Runny Nose

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 23-07-2026