LORINE 10/MG 10/TAB

Indications

Approved Uses

Symptomatic relief of allergic rhinitis (seasonal and perennial) and chronic idiopathic urticaria.

Dosage & Administration

Dosing by Condition

Allergic rhinitis (adults and children ≥6 years): 10mg once daily. Chronic urticaria (adults and children ≥6 years): 10mg once daily. Children 2-5 years: 5mg once daily (requires suitable formulation, not this 10 mg tablet).

Initial Dose

10 mg once daily

Maintenance Dose

10 mg once daily

Maximum Dose

10 mg per day.

Children's Dosage

Children 6 years and older: 10 mg once daily. Children 2-5 years: 5 mg once daily. Safety and efficacy not established in children younger than 2 years of age.

Dose Adjustment Notes

Severe hepatic impairment or severe renal impairment (e.g., CrCl/GFR <30 mL/min): 10 mg every other day (or 5 mg once daily if using a 5 mg formulation).

How to Take

Swallow 1 tablet (10 mg) by mouth once daily with water; may be taken with or without food.

Side Effects

Common Side Effects

Headache, fatigue, dry mouth; less commonly drowsiness/somnolence and nausea.

Safety & Warnings

Contraindications

Hypersensitivity to loratadine or any excipients/ingredients.

Warnings & Precautions

Use with caution in severe hepatic or renal impairment; may cause rare drowsiness; discontinue at least ~48 hours before allergy skin testing; consider excipient-related issues (e.g., lactose intolerance) depending on formulation.

Age Restriction

Not recommended for children under 6 years (for this 10 mg tablet).

Driving Warning

Safe

Drug Interactions

Drug Interactions

CYP3A4/CYP2D6 inhibitors (e.g., ketoconazole, erythromycin, cimetidine) can increase loratadine/desloratadine exposure; additive drowsiness may occur with other CNS depressants (though loratadine is usually non-sedating).

Special Populations

Children

Children 6 years and older: 10 mg once daily. Children 2-5 years: 5 mg once daily. Safety and efficacy not established in children younger than 2 years of age.

Elderly

Standard adult dosing; no specific adjustment required but monitor for any unusual sedation

Kidney Impairment

Severe renal impairment (CrCl <30 mL/min): 10 mg every other day (adults and children ≥6 years); for ages 2-5 years use 5 mg every other day (requires a suitable formulation).

Liver Impairment

Severe hepatic impairment: 10 mg every other day (adults and children ≥6 years); for ages 2-5 years use 5 mg every other day (requires a suitable formulation, not the 10 mg tablet).

Storage & Patient Advice

Missed Dose

Take the missed dose as soon as remembered; if it is close to the next dose, skip the missed dose and resume the regular schedule-do not double doses.

Stopping the Medicine

Safe to stop anytime

Patient Counseling

Take 1 tablet (10 mg) once daily; with or without food. Most people are not drowsy, but if you feel sleepy avoid driving/alcohol/CNS depressants. Do not exceed 10 mg/day. Seek medical advice if symptoms persist/worsen or if you develop signs of a serious allergic reaction. Store below 30°C (per SFDA).

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral histamine H1-receptor antagonist that blocks histamine-mediated allergic symptoms with minimal CNS penetration at recommended doses.

Onset of Action

1-3 hours.

Duration of Effect

Approximately 24 hours (once-daily effect).

Bioavailability

Approximately 40% (oral bioavailability; subject to first-pass metabolism)

Metabolism

Extensive hepatic metabolism primarily via CYP3A4 and CYP2D6 to the active metabolite desloratadine (also called descarboethoxyloratadine)

Product Information

Available Dosage Forms

Tablet (this product: oral tablet). Other loratadine products may exist as syrup/solution depending on market, but this SFDA-registered product is a tablet.

Composition per Dose

Each tablet: 10mg loratadine

Generic Availability

Yes

Symptom Target

Allergy, Runny Nose

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 07-08-2026