LEGALON 140 GM 100 CAP

Benefits & Uses

Primary Benefit

Supports liver health by protecting hepatocytes from toxic damage through antioxidant and anti-inflammatory mechanisms.

Health Claims

Supports liver cell protection against toxic substances; helps maintain normal liver function; provides antioxidant protection of hepatocytes; adjunctive support in chronic liver disease, alcoholic liver disease, and toxic hepatitis

Common Deficiency Symptoms

Not applicable - silymarin is not an essential nutrient; liver-related symptoms it addresses include fatigue, elevated liver enzymes, jaundice, and hepatic inflammation.

Target Population

Adults with liver conditions (hepatitis, fatty liver, cirrhosis), individuals exposed to hepatotoxic substances or medications, those with elevated liver enzymes, and individuals with chronic alcohol use

Scientific Evidence Level

Moderate

Onset Timeline

Liver enzyme improvements may be observed within 4-8 weeks of consistent use; symptomatic relief in chronic liver conditions typically requires 3-6 months of therapy

Usage & Dosage

Serving Size

1 capsule

Servings Per Container

100

Recommended Daily Intake

Adults: 420mg silymarin per day, divided into 3 doses of 140mg each

Upper Tolerable Limit

No officially established upper tolerable limit; doses up to 1,500mg of silymarin daily are generally well-tolerated in clinical use.

Side Effects

Possible Side Effects

Generally well-tolerated; occasional mild gastrointestinal effects (nausea, diarrhea, bloating, abdominal discomfort); mild laxative effect at higher doses; rare allergic reactions in individuals sensitive to Asteraceae family plants

Toxicity Risk

Low

Upper Tolerable Limit

No officially established upper tolerable limit; doses up to 1,500mg of silymarin daily are generally well-tolerated in clinical use.

Safety & Warnings

Contraindications

Known hypersensitivity to silymarin/milk thistle (Silybum marianum) or any excipients; hypersensitivity to plants in the Asteraceae/Compositae family.

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Special Populations

Target Population

Adults with liver conditions (hepatitis, fatty liver, cirrhosis), individuals exposed to hepatotoxic substances or medications, those with elevated liver enzymes, and individuals with chronic alcohol use

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

do not store above 30°c

Science & Evidence

Bioavailability Form

Silymarin standardized dry extract - bioavailability is limited due to poor water solubility; the standardized extract form improves consistency of active flavonolignan delivery compared to raw herb

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Moderate

Onset Timeline

Liver enzyme improvements may be observed within 4-8 weeks of consistent use; symptomatic relief in chronic liver conditions typically requires 3-6 months of therapy

Food Sources

Milk thistle (Silybum marianum) seeds are the only significant natural source of silymarin; not meaningfully present in common dietary foods

Product Information

Supplement Type

Herbal

Allergen Info

May contain traces of milk thistle plant allergens; individuals with allergies to plants in the Asteraceae/Compositae family (ragweed, chrysanthemums, marigolds, daisies) should use with caution; no gluten, dairy, or soy declared

Certification

SFDA registered (Registration No. 4-1050-2019); manufactured by Madaus AG, Germany under GMP standards

Plant Source

Milk Thistle (Silybum marianum) - fruit/seed extract

Standardized Extract

Standardized to provide 140mg Silymarin per capsule from 173mg-186.7mg dried extract (approximately 75% silymarin content)