DESLIN 5/MG FC TAB 30/TAB

Indications

Approved Uses

Allergic rhinitis (seasonal and perennial) and chronic idiopathic urticaria.

Off-Label Uses

Allergic conjunctivitis; pruritus associated with atopic dermatitis (symptomatic relief).

Dosage & Administration

Dosing by Condition

Allergic rhinitis or chronic idiopathic urticaria: Adults and adolescents ≥12 years: 5 mg orally once daily.

Initial Dose

5 mg once daily.

Maintenance Dose

5 mg once daily.

Maximum Dose

5 mg once daily.

Children's Dosage

Not recommended for children under 12 years with this tablet formulation; pediatric doses specified for oral solution or other forms.

Dose Adjustment Notes

In renal or hepatic impairment, consider a starting regimen of 5 mg every other day (particularly in severe impairment).

How to Take

Swallow the 5 mg film-coated tablet whole with water; may be taken with or without food; take once daily.

Side Effects

Common Side Effects

Headache, pharyngitis, dry mouth, fatigue, somnolence, myalgia, nausea, dizziness, dysmenorrhea.

Side Effect Frequency

Common (≥1% to <10%): fatigue, dry mouth, headache; other reported adverse effects include somnolence and dizziness (frequency varies by source/age group). Rare/very rare: hypersensitivity reactions (including anaphylaxis/angioedema), tachycardia/palpitations, seizures, and hepatitis/elevated liver enzymes.

Safety & Warnings

Contraindications

Hypersensitivity to desloratadine, loratadine, or any excipients/components of the formulation.

Warnings & Precautions

Use with caution in severe renal impairment and severe hepatic impairment; caution in patients with a history of seizures (particularly children); monitor for hypersensitivity reactions.

Age Restriction

This product is a 5 mg film‑coated tablet; use is generally for adults and adolescents ≥12 years (younger children require age‑appropriate formulations such as oral solution).

Driving Warning

May Cause Drowsiness

Drug Interactions

Drug Interactions

Potential increased desloratadine exposure with strong/moderate metabolic inhibitors reported in studies (e.g., ketoconazole, erythromycin, azithromycin, fluoxetine, cimetidine); alcohol/CNS depressants may add to drowsiness in susceptible patients.

Interaction Severity

MODERATE: Strong/moderate CYP/P-gp inhibitors such as ketoconazole, erythromycin, fluoxetine, and cimetidine may increase desloratadine exposure; clinical significance is usually low. MINOR/CAUTION: Alcohol/CNS depressants-possible additive drowsiness in susceptible patients.

Food Interaction

No restriction.

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

Not recommended for children under 12 years with this tablet formulation; pediatric doses specified for oral solution or other forms.

Elderly

Standard adult dosing; no specific dose adjustment required, but use with caution if renal function is reduced

Kidney Impairment

Adults with renal impairment: 5 mg every other day.

Liver Impairment

Adults with hepatic impairment: 5 mg every other day.

Storage & Patient Advice

Stopping the Medicine

Safe to stop anytime

Overdose

Symptoms may include somnolence, tachycardia, and headache; manage with standard supportive care and consider measures to reduce absorption if recent ingestion; desloratadine is not removed by hemodialysis; seek medical attention/poison center advice.

Patient Counseling

Take 1 tablet (5 mg) once daily with or without food; may cause drowsiness in some-use caution with driving until you know your response; avoid alcohol if it makes you sleepy; do not exceed the recommended dose; store below 30°C; seek medical advice if pregnant/breastfeeding or if you have significant kidney/liver disease or persistent/worsening symptoms.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral histamine H1-receptor antagonist that blocks histamine-mediated allergic symptoms (e.g., sneezing, rhinorrhea, pruritus, wheals).

Onset of Action

Within 3 hours.

Duration of Effect

24 hours.

Bioavailability

Desloratadine is well absorbed with measurable plasma levels within ~30 minutes; Tmax occurred at approximately 3 hours post dose; neither food nor grapefruit juice had an effect on the bioavailability.

Metabolism

Hepatic metabolism: desloratadine is metabolized to 3-hydroxydesloratadine (followed by glucuronidation); the specific CYP enzymes responsible are not definitively established, and a subset of patients are poor metabolizers with higher systemic exposure.

Product Information

Available Dosage Forms

Film-coated tablet; oral solution (syrup).

Composition per Dose

Each film-coated tablet: 5 mg desloratadine

Generic Availability

Yes

OTC Alternatives

Loratadine, cetirizine, and fexofenadine (typical adult OTC doses: loratadine 10 mg daily; cetirizine 10 mg daily; fexofenadine 120-180 mg daily depending on indication).

Symptom Target

Allergy, Runny Nose

Sedating

No

Legal Disclaimer - Al Mujtama Pharmacy

The product information provided is derived from verified pharmaceutical references and is intended for general health education only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Al Mujtama Pharmacy assumes no legal or medical liability for:

• Any therapeutic decision made based on the information displayed without consulting a licensed physician or pharmacist
• Any discrepancy between the information provided and the product's package insert or SFDA guidelines
• Any misuse of medication resulting from personal interpretation of the content displayed

Important notice: Drug formulations and instructions may vary between production batches. Always rely on the leaflet included inside the product packaging you have, and consult your pharmacist or physician before starting, adjusting, or discontinuing any medication.

By using this content, you acknowledge that you have read this disclaimer and agree that Al Mujtama Pharmacy bears no liability arising from reliance on this information as a substitute for direct medical consultation.

Your health is a trust - always consult your doctor first.