BLUM-D 50.000/I.U 20/FC TAB

Benefits & Uses

Primary Benefit

Corrects and prevents vitamin D deficiency, supporting bone health, calcium absorption, and immune function

Health Claims

Supports normal bone and teeth mineralization; maintains normal muscle function; contributes to normal immune system function; supports calcium and phosphorus absorption; correction of vitamin D deficiency

Common Deficiency Symptoms

Fatigue, bone pain, muscle weakness, frequent infections, depression, hair loss, impaired wound healing, rickets (children), osteomalacia (adults)

Target Population

Adults with confirmed vitamin D deficiency or insufficiency; individuals with limited sun exposure; elderly adults; obese individuals; patients with malabsorption syndromes; dark-skinned individuals; postmenopausal women; patients on medications that impair vitamin D metabolism

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks of supplementation; deficiency correction typically achieved in 8-12 weeks with weekly high-dose therapy; bone density improvements observed after 6-12 months of sustained adequate levels

Usage & Dosage

Suggested Use

For treatment of deficiency, a typical loading dose is one 50,000 IU tablet taken once weekly for 6-8 weeks, followed by a lower maintenance dose, as directed by a healthcare professional.

Serving Size

1 film-coated tablet

Servings Per Container

20

Best Time to Take

With meals (preferably a fat-containing meal for optimal absorption)

Recommended Daily Intake

Adults: 600-800 IU/day (15-20 mcg); therapeutic dosing for deficiency: 1,500-2,000 IU/day maintenance after repletion

Upper Tolerable Limit

4,000 IU/day for adults (general population); therapeutic doses up to 10,000 IU/day used under medical supervision

Absorption Enhancers

Dietary fat (increases micellar solubilization and lymphatic absorption); magnesium (cofactor for vitamin D metabolism); bile acids

Absorption Inhibitors

Orlistat (blocks fat absorption, reducing vitamin D uptake); cholestyramine and colestipol (bile acid sequestrants impair absorption); mineral oil; high-dose calcium supplements taken simultaneously

Side Effects

Possible Side Effects

At high or prolonged doses: hypercalcemia (nausea, vomiting, constipation, polyuria, polydipsia, weakness, confusion), hypercalciuria, nephrolithiasis, soft tissue calcification; generally well-tolerated at prescribed therapeutic doses

Toxicity Risk

Medium

Upper Tolerable Limit

4,000 IU/day for adults (general population); therapeutic doses up to 10,000 IU/day used under medical supervision

Safety & Warnings

Contraindications

Known hypersensitivity to cholecalciferol or excipients; hypercalcemia and/or hypercalciuria; hypervitaminosis D; nephrolithiasis/nephrocalcinosis; severe renal impairment (use is contraindicated or requires specialist supervision depending on local labeling).

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Children Suitability

Not recommended for self-use in children without medical supervision; dosing must be individualized by a physician based on age and serum 25(OH)D levels

Interactions

Medication Interactions

Thiazide diuretics (increase hypercalcemia risk); digoxin (hypercalcemia increases toxicity risk); corticosteroids (reduce vitamin D efficacy); orlistat and cholestyramine (reduce absorption); antiepileptics such as phenytoin and phenobarbital (accelerate vitamin D catabolism)

Supplement Interactions

High-dose calcium supplements taken concurrently increase hypercalcemia risk; magnesium supplementation supports vitamin D activation

Synergistic Nutrients

Vitamin K2 (MK-7) - directs calcium to bones and away from arteries; Calcium - bone mineralization; Magnesium - essential cofactor for vitamin D hydroxylation and activation; Zinc - supports bone matrix formation

Special Populations

Target Population

Adults with confirmed vitamin D deficiency or insufficiency; individuals with limited sun exposure; elderly adults; obese individuals; patients with malabsorption syndromes; dark-skinned individuals; postmenopausal women; patients on medications that impair vitamin D metabolism

Children Suitability

Not recommended for self-use in children without medical supervision; dosing must be individualized by a physician based on age and serum 25(OH)D levels

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

store below 30°c

Storage Conditions

Store below 30°C in a cool, dry place. Keep away from direct sunlight and moisture. Keep out of reach of children

Patient Counseling

High-dose cholecalciferol (vitamin D3) 50,000 IU film‑coated tablet for oral use; take only as prescribed (commonly once weekly for deficiency, then maintenance as directed). Take with/after a meal (preferably containing fat) to improve absorption. Do not exceed the prescribed dose or combine with other high‑dose vitamin D/calcium products unless instructed; overdose can cause hypercalcemia-seek care if nausea/vomiting, constipation, weakness/confusion, polyuria/polydipsia occur. Inform the prescriber about kidney disease, history of kidney stones, hyperparathyroidism/sarcoidosis or other granulomatous disease, and all medicines-especially thiazide diuretics and digoxin (higher hypercalcemia/arrhythmia risk). Monitoring of serum 25‑OH vitamin D and calcium (± phosphate/creatinine) is recommended during high‑dose therapy. Store below 30°C in the blister.

Science & Evidence

Bioavailability Form

Cholecalciferol (Vitamin D3) - the most bioavailable form of vitamin D, approximately 87% more effective than ergocalciferol (D2) at raising and sustaining serum 25(OH)D levels

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks of supplementation; deficiency correction typically achieved in 8-12 weeks with weekly high-dose therapy; bone density improvements observed after 6-12 months of sustained adequate levels

Food Sources

Fatty fish (salmon, mackerel, sardines), cod liver oil, egg yolks, beef liver, UV-exposed mushrooms, fortified milk and dairy products, fortified cereals

Product Information

Supplement Type

Vitamin

Certification

SFDA registered (Registration No. 1601210418); manufactured under GMP-compliant facility in Saudi Arabia

Suitable for Vegans

No

Vitamin D Form

D3

Calcium Included

No

Vitamin K Included

No