JP PRIMA D3 10000/IU SG CAP 30/SG CAP

Benefits & Uses

Primary Benefit

Supports bone health, calcium absorption, and immune function by replenishing vitamin D3 levels

Health Claims

Contributes to normal absorption and utilization of calcium and phosphorus; supports maintenance of normal bones and teeth; supports normal muscle function; contributes to normal immune system function; helps maintain normal blood calcium levels

Common Deficiency Symptoms

Fatigue, bone pain, muscle weakness, frequent infections, depression, hair loss, impaired wound healing, rickets in children, osteomalacia in adults

Target Population

Adults with confirmed or suspected vitamin D deficiency, individuals with limited sun exposure, elderly adults, individuals with malabsorption syndromes, obese individuals, patients on medications that impair vitamin D metabolism, people with dark skin pigmentation in low-sunlight regions

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks; significant correction of deficiency achieved in 4-8 weeks with high-dose therapy; bone density improvements observed after 3-6 months of sustained adequate levels

Usage & Dosage

Suggested Use

Take 1 softgel capsule daily with a fat-containing meal, or as directed by a physician

Serving Size

1 softgel capsule

Servings Per Container

30

Best Time to Take

With meals

Recommended Daily Intake

Adults: 600-800 IU/day (15-20 mcg); therapeutic doses up to 10000 IU/day under medical supervision for deficiency correction

Upper Tolerable Limit

4000 IU/day (100 mcg) for general adult population; up to 10000 IU/day may be used therapeutically under medical supervision

Absorption Enhancers

Take with a fat-containing meal to maximize absorption; magnesium is required for vitamin D metabolism and activation; adequate bile salts enhance intestinal uptake

Absorption Inhibitors

Orlistat (fat absorption blocker) significantly reduces vitamin D absorption; cholestyramine and colestipol reduce absorption; mineral oil interferes with fat-soluble vitamin uptake

Side Effects

Possible Side Effects

At excessive doses: hypercalcemia (nausea, vomiting, weakness, frequent urination, kidney stones, constipation, confusion); generally well-tolerated at prescribed therapeutic doses under medical supervision

Toxicity Risk

Medium

Upper Tolerable Limit

4000 IU/day (100 mcg) for general adult population; up to 10000 IU/day may be used therapeutically under medical supervision

Safety & Warnings

Contraindications

Known hypersensitivity to colecalciferol/excipients; hypercalcemia and/or hypercalciuria; hypervitaminosis D; nephrolithiasis/nephrocalcinosis; severe renal impairment (especially with reduced ability to activate vitamin D). Use with caution (not absolute contraindications) in granulomatous diseases (e.g., sarcoidosis), primary hyperparathyroidism, and malignancy/lymphoma due to increased risk of hypercalcemia.

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Children Suitability

Not recommended for children without medical supervision; 10000 IU is a high therapeutic dose intended for adults under physician guidance

Interactions

Medication Interactions

Thiazide diuretics increase risk of hypercalcemia when combined with high-dose vitamin D; corticosteroids reduce vitamin D efficacy; anticonvulsants (phenytoin, phenobarbital) accelerate vitamin D catabolism; orlistat reduces absorption; digoxin toxicity risk increases with hypercalcemia induced by excess vitamin D

Supplement Interactions

High-dose calcium supplements combined with high-dose vitamin D increase hypercalcemia risk; vitamin A at high doses may antagonize vitamin D activity

Synergistic Nutrients

Vitamin K2 (MK-7) directs calcium to bones and away from arteries; magnesium activates vitamin D metabolism; calcium works synergistically with vitamin D for bone mineralization; zinc and boron support bone health alongside vitamin D

Special Populations

Target Population

Adults with confirmed or suspected vitamin D deficiency, individuals with limited sun exposure, elderly adults, individuals with malabsorption syndromes, obese individuals, patients on medications that impair vitamin D metabolism, people with dark skin pigmentation in low-sunlight regions

Children Suitability

Not recommended for children without medical supervision; 10000 IU is a high therapeutic dose intended for adults under physician guidance

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

store below 30°c

Storage Conditions

Store below 30°C.

Patient Counseling

Prescription-only high-dose cholecalciferol (vitamin D3) 10,000 IU softgel for oral use-take only as prescribed and avoid long-term self-use; take with/after a meal (preferably containing fat) to improve absorption; monitoring of serum 25(OH)D and calcium (± renal function) may be required, especially with prolonged/high-dose therapy; seek medical advice if symptoms of hypercalcemia/vitamin D toxicity occur (e.g., nausea/vomiting, constipation, weakness, excessive thirst, frequent urination, confusion); inform the prescriber about all medicines and conditions-caution with thiazide diuretics and digoxin and in patients with hypercalcemia, nephrolithiasis, or significant renal impairment.

Science & Evidence

Bioavailability Form

Vitamin D3 (cholecalciferol) - the most bioavailable form of vitamin D, approximately 87% more effective than D2 (ergocalciferol) at raising and sustaining serum 25(OH)D levels

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks; significant correction of deficiency achieved in 4-8 weeks with high-dose therapy; bone density improvements observed after 3-6 months of sustained adequate levels

Food Sources

Fatty fish (salmon, mackerel, sardines, tuna), cod liver oil, egg yolks, beef liver, UV-exposed mushrooms, fortified milk and dairy products, fortified cereals

Product Information

Supplement Type

Vitamin

Allergen Info

Contains gelatin (animal-derived softgel capsule, likely bovine or porcine); may contain soybean oil as carrier; free from gluten and dairy - full allergen declaration should be confirmed on product label

Certification

SFDA registered (Registration No. 709234152); manufactured by Jamjoom Pharmaceuticals Factory Company (GMP-compliant facility, Saudi Arabia)

Vitamin D Form

D3

Calcium Included

No

Vitamin K Included

No