Frequently bought together

Brand : AVOCOM

AVOCOM-M CREAM 50 MG

37.25

Sku : I-026309
Key features
AVOCOM-M CREAM 50 MG is a prescription topical cream containing the antifungal miconazole nitrate 2% and the medium‑potency corticosteroid mometasone furoate 0.1%. Miconazole inhibits fungal 14‑α‑demethylase to disrupt ergosterol synthesis and compromise the fungal cell membrane, while mometasone activates glucocorticoid receptors to suppress inflammatory gene transcription and reduce erythema, pruritus and swelling. It is indicated for inflammatory superficial fungal skin infections responsive to miconazole, including tinea corporis, tinea cruris, tinea pedis and cutaneous candidiasis. Supplied as a 50 g cream tube for prescription dispensing.
- Brand: AVOCOM
- Active Ingredient: MICONAZOLE NITRATE 2%, MOMETASONE FUROATE 0.1%
- Strength: 2,0.1%
- Dosage Form: Cream
- Pack Size: 50 g
- Route: Topical
- Prescription Status: Prescription
- Therapeutic Class: Dermatological
- Pharmacological Group: Antifungals (Topical)
- Drug Class: Topical imidazole (azole) antifungal + topical corticosteroid (mometasone; medium potency) combination.
- Manufacturer: (Avalon Pharma) Middle East Pharmaceutical Industries Co. Ltd
- Country of Origin: Saudi Arabia
- SFDA Registration No.: 2004257237
- Shelf Life: 24 months
- Storage: store below 30°c
- Skin Condition: Fungal
- Steroid Potency: Moderate

Frequently bought together

Description

Specification

Indications

Approved Uses

Inflammatory superficial fungal skin infections responsive to miconazole with a prominent inflammatory component, including tinea corporis, tinea cruris, tinea pedis, and cutaneous candidiasis.

Dosage & Administration

Dose Adjustment Notes

No renal/hepatic dose adjustment is applicable for topical use; minimize systemic corticosteroid exposure by using the smallest amount for the shortest duration and avoiding large areas/occlusion.

Safety & Warnings

Driving Warning

Safe

Drug Interactions

Food Interaction

No food interactions (not applicable for topical administration).

Alcohol Interaction

Safe

Special Populations

Kidney Impairment

No dose adjustment (topical).

Liver Impairment

No dose adjustment (topical).

Pharmacology

Mechanism of Action

Miconazole inhibits fungal 14-α-demethylase (CYP450), reducing ergosterol synthesis and disrupting the fungal cell membrane; mometasone activates glucocorticoid receptors to suppress inflammatory gene transcription and mediator release, reducing erythema, pruritus, and inflammation.

Bioavailability

Systemic absorption is minimal with topical use: miconazole is typically <1% absorbed through intact skin; mometasone furoate has low systemic bioavailability (about 0.4% reported for topical formulations on intact skin), increasing with large areas, occlusion, inflammation, or prolonged use.