VOLTIC 50/MG TAB 20/TAB

Indications

Approved Uses

Symptomatic treatment of pain and inflammation in rheumatic conditions such as osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis; and short‑term treatment of acute pain conditions (e.g., postoperative/dental/musculoskeletal pain) and primary dysmenorrhea (per local labeling).

Dosage & Administration

Dosing by Condition

Adults (diclofenac sodium enteric‑coated): Osteoarthritis/Rheumatoid arthritis: 50 mg 2-3 times daily (usual max 150 mg/day). Ankylosing spondylitis: 25 mg 4 times daily or 50 mg 2-3 times daily (max 150 mg/day). Primary dysmenorrhea/acute pain: 50 mg up to 3 times daily (max 150 mg/day) for the shortest duration.

Initial Dose

For osteoarthritis: 50 mg two or three times a day; for rheumatoid arthritis: 50 mg three times a day.

Maintenance Dose

50mg two or three times a day.

Maximum Dose

150 mg/day for osteoarthritis; 200 mg/day for rheumatoid arthritis (dosages above 225 mg/day not recommended).

Dose Adjustment Notes

Use the lowest effective dose for the shortest duration. No routine dose adjustment is defined for mild-moderate hepatic or renal impairment, but start low and monitor; avoid use in severe hepatic impairment and in severe renal impairment/advanced kidney disease; in older adults use the lowest effective dose with close monitoring.

How to Take

Swallow the 50 mg enteric‑coated tablet whole with water; do not crush, chew, or split. Take with or after food (or milk) if gastric upset occurs; follow prescribed schedule.

Safety & Warnings

Contraindications

Hypersensitivity to diclofenac/other NSAIDs; history of NSAID/aspirin-induced asthma/urticaria (AERD); active GI ulceration or bleeding; perioperative pain in CABG surgery; third trimester of pregnancy.

Warnings & Precautions

Use the lowest effective dose for the shortest duration; increased risk of CV thrombotic events (caution in CVD/risk factors) and serious GI events (higher risk in elderly/prior ulcer/anticoagulants); monitor for renal toxicity (CKD, HF, dehydration, diuretics/ACEi/ARB), hepatotoxicity (periodic LFTs if prolonged), hypertension/edema/HF worsening; avoid in aspirin-exacerbated respiratory disease; discontinue if rash or hypersensitivity occurs.

Drug Interactions

Food Interaction

Take with food

Special Populations

Pregnancy

Avoid in third trimester; Pregnancy Category C (first and second trimesters)

Elderly

Use lowest effective dose; start at 25-50mg per dose; monitor renal function, blood pressure, and GI symptoms closely; increased risk of adverse events

Storage & Patient Advice

Patient Counseling

Take the enteric-coated tablet whole with water (do not crush/chew); preferably with/after food to reduce GI upset. Use the lowest effective dose for the shortest duration. Avoid taking other NSAIDs (e.g., ibuprofen, naproxen) or aspirin for pain unless prescriber advises; limit alcohol due to GI bleeding risk. Seek urgent care for GI bleeding (black/tarry stools, vomiting blood), severe abdominal pain, chest pain/shortness of breath/weakness (CV events), or signs of allergy/serious rash. Inform the prescriber about history of ulcer/bleeding, cardiovascular disease, hypertension, kidney/liver disease, and all concomitant medicines. Store as labeled (≤30°C) and keep out of reach of children; prescription-only-do not share.

Pharmacology

Mechanism of Action

Reversibly inhibits COX‑1 and COX‑2, decreasing prostaglandin synthesis, which reduces inflammation, pain, and fever.

Onset of Action

Analgesic onset typically ~30-60 minutes for immediate‑release; for enteric‑coated tablets onset may be delayed to ~1-2 hours.

Half-Life

1.2-2 hours.

Bioavailability

Approximately 50% (range ~50-60%) systemic bioavailability due to significant first-pass metabolism; enteric coating delays absorption (later Tmax) but does not meaningfully reduce extent of absorption.

Protein Binding

>99% protein bound (mainly to albumin).

Product Information

Available Dosage Forms

For diclofenac (INN) globally: oral immediate‑release tablets/capsules, enteric‑coated (delayed‑release) tablets, extended‑release tablets, suppositories, injectable formulations (typically IM; IV in some settings), topical preparations (gel/solution/patch), and ophthalmic drops.

Composition per Dose

Each enteric-coated tablet: 50mg diclofenac sodium

Generic Availability

Yes

Pain Type

General, Muscular, Joint, Migraine

Nsaid

Yes

Opioid

No

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