TOPFEROL 50000 IU 8 TAB

Benefits & Uses

Primary Benefit

Corrects and prevents vitamin D deficiency, supporting bone health, calcium absorption, and immune function

Health Claims

Correction of vitamin D deficiency and insufficiency; supports normal bone mineralization and maintenance; contributes to normal muscle function; supports immune system function; aids intestinal calcium and phosphorus absorption

Common Deficiency Symptoms

Fatigue, bone pain, muscle weakness, frequent infections, depression, hair loss, impaired wound healing, rickets in children, osteomalacia in adults

Target Population

Adults diagnosed with vitamin D deficiency or insufficiency; individuals with limited sun exposure; elderly patients; patients with malabsorption syndromes; individuals with obesity; patients on medications that impair vitamin D metabolism

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks of weekly dosing; deficiency correction typically achieved within 8-12 weeks of therapeutic dosing; bone density improvements require 3-6 months of sustained adequate levels

Usage & Dosage

Suggested Use

Take 1 tablet as directed by a physician, typically once weekly or as prescribed, with a fat-containing meal

Serving Size

1 film-coated tablet

Servings Per Container

8

Best Time to Take

With meals (preferably with the largest fat-containing meal of the day)

Recommended Daily Intake

Adults: 600-800 IU/day (15-20 mcg); therapeutic doses of 50,000 IU are prescribed weekly or as directed by a physician for deficiency correction

Upper Tolerable Limit

4,000 IU/day (100 mcg) for adults as a general population UL; therapeutic doses above this level require medical supervision and monitoring of serum calcium and 25(OH)D

Absorption Enhancers

Dietary fat (increases micellar solubilization and lymphatic absorption); magnesium (cofactor for vitamin D metabolism); bile acids

Absorption Inhibitors

Orlistat (blocks fat absorption, significantly reduces vitamin D absorption); cholestyramine and colestipol (bile acid sequestrants impair absorption); mineral oil; high-dose calcium supplements taken simultaneously

Side Effects

Possible Side Effects

At prescribed therapeutic doses: generally well-tolerated. Excessive or prolonged high-dose use may cause hypercalcemia, hypercalciuria, nausea, vomiting, constipation, polyuria, polydipsia, weakness, confusion, and nephrocalcinosis

Toxicity Risk

Medium

Upper Tolerable Limit

4,000 IU/day (100 mcg) for adults as a general population UL; therapeutic doses above this level require medical supervision and monitoring of serum calcium and 25(OH)D

Safety & Warnings

Contraindications

Known hypersensitivity to cholecalciferol/excipients; hypercalcemia and/or hypercalciuria; hypervitaminosis D; conditions predisposing to hypercalcemia (e.g., primary hyperparathyroidism, granulomatous diseases such as sarcoidosis); severe renal impairment/renal failure; nephrolithiasis (calcium stones) or severe nephrocalcinosis.

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Children Suitability

Not recommended under 18 unless prescribed by a physician.

Interactions

Medication Interactions

Orlistat reduces absorption; thiazide diuretics increase risk of hypercalcemia when combined with high-dose vitamin D; corticosteroids impair vitamin D metabolism; anticonvulsants (phenytoin, phenobarbital) accelerate vitamin D catabolism; rifampicin reduces vitamin D efficacy

Supplement Interactions

High-dose calcium supplements taken concurrently increase hypercalcemia risk; magnesium deficiency impairs conversion to active form; iron absorption is not directly affected

Synergistic Nutrients

Vitamin K2 (MK-7) directs calcium to bones and away from arteries; magnesium (essential cofactor for vitamin D hydroxylation); calcium (vitamin D enhances intestinal calcium absorption); zinc (supports vitamin D receptor function)

Special Populations

Target Population

Adults diagnosed with vitamin D deficiency or insufficiency; individuals with limited sun exposure; elderly patients; patients with malabsorption syndromes; individuals with obesity; patients on medications that impair vitamin D metabolism

Children Suitability

Not recommended under 18 unless prescribed by a physician.

Pregnancy Safety

Consult Doctor

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

store below 30°c

Storage Conditions

Store below 30°C.

Patient Counseling

Oral cholecalciferol 50,000 IU film‑coated tablet: take exactly as prescribed (commonly once weekly for deficiency, but follow the prescriber’s schedule-do not take daily unless specifically instructed). Take with/after a meal (preferably containing fat) to improve absorption. Do not exceed the dose or add other vitamin D/calcium supplements unless approved. Monitoring of serum 25‑OH vitamin D and calcium (± phosphate/creatinine) is recommended during high‑dose therapy. Seek medical advice urgently if symptoms of hypercalcemia/vitamin D toxicity occur (e.g., nausea/vomiting, constipation, excessive thirst/polyuria, weakness, confusion).

Science & Evidence

Bioavailability Form

Cholecalciferol (Vitamin D3) - the most bioavailable form of vitamin D, approximately 87% more effective than ergocalciferol (D2) at raising and sustaining serum 25-hydroxyvitamin D levels

Water or Fat Soluble

Fat-soluble

Scientific Evidence Level

Strong

Onset Timeline

Serum 25(OH)D levels begin rising within 1-2 weeks of weekly dosing; deficiency correction typically achieved within 8-12 weeks of therapeutic dosing; bone density improvements require 3-6 months of sustained adequate levels

Food Sources

Fatty fish (salmon, mackerel, sardines, tuna), cod liver oil, egg yolks, beef liver, UV-exposed mushrooms, fortified milk and dairy products, fortified cereals

Product Information

Supplement Type

Vitamin

Certification

SFDA registered (Registration No. 2001268967); GMP manufactured by Pharma International Co., Jordan

Suitable for Vegetarians

Yes

Suitable for Vegans

No

Vitamin D Form

D3

Calcium Included

No

Vitamin K Included

No