RESOLVE PLUS 1% CREAM 30G

Dosage & Administration

Dosing by Condition

Inflamed tinea/cutaneous candidiasis: apply thinly twice daily initially; once inflammation/itch improves (often within a few days), step down to an antifungal-only product to complete a typical total antifungal course (commonly 2-4 weeks; tinea pedis often requires longer than tinea corporis/cruris).

Maximum Dose

Apply a thin layer twice daily; use the smallest amount for the shortest duration (typically up to 7 days for the steroid-containing combination, then switch to antifungal-only if needed); avoid large areas/occlusion unless directed

Dose Adjustment Notes

Use the lowest effective amount for the shortest duration; avoid prolonged continuous use and avoid occlusion (especially in flexures/groin) unless directed; reassess if not improving within ~1-2 weeks and switch to antifungal-only once inflammation settles.

How to Take

Clean and dry the affected area. Apply a thin layer to the affected skin (and a small margin of surrounding skin) and gently rub in, usually twice daily. Wash hands after application (and before application if hands are contaminated); avoid contact with eyes/mucosa and do not occlude unless directed.

Side Effects

Common Side Effects

Application-site burning/stinging, irritation, pruritus, erythema, dryness/peeling; less commonly contact dermatitis; with prolonged/occlusive use: steroid effects such as skin atrophy/striae/telangiectasia.

Safety & Warnings

Contraindications

Hypersensitivity to miconazole nitrate, hydrocortisone, or any excipient; viral skin infections (e.g., herpes simplex, varicella); tuberculous or syphilitic skin lesions; acne vulgaris; rosacea; perioral dermatitis; ulcerative skin conditions

Drug Interactions

Drug Interactions

May potentiate oral anticoagulants (e.g., warfarin) even with topical use-monitor INR; other systemic interactions are unlikely at standard topical use

Food Interaction

No restriction

Alcohol Interaction

Safe

Special Populations

Pregnancy

Caution

Breastfeeding

Caution

Elderly

Standard adult dosing. Use with caution on fragile or atrophic skin common in elderly patients; limit duration of use.

Kidney Impairment

No adjustment needed

Storage & Patient Advice

Missed Dose

Apply when remembered; if close to the next scheduled application, skip the missed dose and continue as normal-do not apply extra to make up for it.

Monitoring Requirements

No routine monitoring for short-term use. Monitor for signs of HPA axis suppression (fatigue, weakness, hypotension) with prolonged use over large areas. Monitor INR in patients on warfarin.

Pharmacology

Mechanism of Action

Miconazole inhibits ergosterol synthesis (via fungal 14-α-demethylase), disrupting cell membrane integrity; hydrocortisone activates glucocorticoid receptors to suppress local inflammatory mediator production, reducing erythema, pruritus, and swelling.

Metabolism

Miconazole (if systemically absorbed): hepatic metabolism (primarily CYP3A4 and CYP2C9); Hydrocortisone (if systemically absorbed): rapid hepatic metabolism (with additional peripheral tissue metabolism) to inactive metabolites.

Protein Binding

Miconazole: ~91-93% protein bound; Hydrocortisone: >90% protein bound (largely to corticosteroid-binding globulin and albumin).

Product Information

Available Dosage Forms

Cream (30 g tube).

Skin Condition

Fungal

Steroid Potency

Mild

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 07-06-2026