OPTIFLOX EYE DROPS 5ML

Indications

Approved Uses

Bacterial conjunctivitis and bacterial corneal ulcer (keratitis) caused by susceptible organisms.

Off-Label Uses

May be used off-label for perioperative/post-procedural ocular infection prophylaxis when directed by ophthalmology (practice varies).

Dosage & Administration

Dosing by Condition

Bacterial conjunctivitis: Days 1-2: 1-2 drops in affected eye(s) every 2-4 hours while awake; Days 3-7: 1-2 drops four times daily. Bacterial corneal ulcer: Days 1-2: 1-2 drops every 30 minutes while awake and 4 & 6 hours after retiring; Days 3-7: 1-2 drops hourly while awake; Days 8-9: 1-2 drops four times daily (typical total course up to ~14 days; longer only if directed by ophthalmology).

Initial Dose

1-2 drops in the affected eye(s) every 2-4 hours while awake for the first 2 days

Maintenance Dose

1-2 drops in the affected eye(s) four times daily

Children's Dosage

Approved for use in children aged 1 year and older at the same dose as adults

Dose Adjustment Notes

No dose adjustment is required in renal or hepatic impairment for ophthalmic use due to minimal systemic absorption.

Side Effects

Side Effect Frequency

Most common: transient ocular burning/stinging/irritation after instillation; other reported effects include redness, itching, tearing, blurred vision/photophobia, foreign-body sensation, and eyelid edema/hypersensitivity (serious allergic reactions are rare).

Safety & Warnings

Contraindications

Hypersensitivity to ofloxacin, other fluoroquinolones, or any component of the formulation

Warnings & Precautions

For ophthalmic use only (not for injection/oral use); stop and seek care at first sign of hypersensitivity; avoid contact lenses during active infection/treatment; avoid contaminating dropper tip; prolonged use may cause overgrowth of non-susceptible organisms including fungi; if preservative (e.g., benzalkonium chloride) is present, it may irritate eyes and discolor soft lenses

Age Restriction

Not recommended/insufficient safety data in infants <1 year; use only if clearly needed under specialist supervision

Drug Interactions

Drug Interactions

No clinically significant drug interactions expected; formal interaction studies are limited/not conducted

Interaction Severity

No clinically significant drug interactions are expected with ophthalmic ofloxacin; separate from other eye drops by ≥5 minutes to avoid physical washout.

Food Interaction

No restriction

Alcohol Interaction

Safe

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Caution

Children

Approved for use in children aged 1 year and older at the same dose as adults

Elderly

Standard adult dosing

Kidney Impairment

No dose adjustment needed for renal impairment (ophthalmic use)

Liver Impairment

No dose adjustment needed for hepatic impairment (ophthalmic use)

Storage & Patient Advice

Stopping the Medicine

Complete the full prescribed course; do not stop early even if symptoms improve unless advised due to intolerance/allergy

Pharmacology

Mechanism of Action

Inhibits bacterial DNA gyrase (topoisomerase II) and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death

Half-Life

Systemic ofloxacin elimination half-life is ~4-7 hours; for ophthalmic use the clinically relevant half-life is not well-defined because systemic absorption is minimal.

Metabolism

Ofloxacin undergoes minimal metabolism and is eliminated largely unchanged in urine; after ophthalmic administration, systemic metabolism is negligible due to minimal absorption.

Product Information

Available Dosage Forms

Eye drops, solution (ophthalmic)

Composition per Dose

Each mL: 3 mg ofloxacin (0.3%)

Generic Availability

Yes

OTC Alternatives

No OTC alternative

Target Organ

Eye

Preservative Free

No

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