LORINE 1SYRUP 100ML

Indications

Approved Uses

Seasonal allergic rhinitis, perennial allergic rhinitis, chronic idiopathic urticaria, allergic conjunctivitis

Off-Label Uses

Off-label: pruritus (e.g., atopic dermatitis-related itch) and other histamine-mediated itching conditions; adjunctive use in some allergic/asthma phenotypes is sometimes described but is not a primary guideline-indicated therapy.

Dosage & Administration

Dosing by Condition

Allergic rhinitis and chronic idiopathic urticaria: Adults and adolescents ≥12 years: 5 mg once daily (10 mL of 0.5 mg/mL syrup). Children 6-11 years: 2.5 mg once daily (5 mL). Children 1-5 years: 1.25 mg once daily (2.5 mL). Children 6-11 months: 1 mg once daily (2 mL).

Initial Dose

Adults and adolescents ≥12 years: 5 mg (10 mL) once daily.

Maintenance Dose

Adults and adolescents ≥12 years: 5 mg (10 mL) once daily.

Maximum Dose

Adults and adolescents ≥12 years: 5 mg (10 mL) once daily.

Children's Dosage

6-11 months: 1 mg (2 ml) once daily; 1-5 years: 1.25 mg (2.5 ml) once daily; 6-11 years: 2.5 mg (5 ml) once daily; ≥12 years: 5 mg (10 ml) once daily

How to Take

Oral use once daily; may be taken with or without food. Shake the bottle well before each dose and measure using a calibrated oral syringe/medicine spoon/cup (preferably the provided device).

Side Effects

Common Side Effects

Headache, fatigue, dry mouth, nausea, pharyngitis, myalgia, somnolence (rare at therapeutic doses)

Side Effect Frequency

Adults/adolescents: ≥2%: pharyngitis, dry mouth, myalgia, fatigue, somnolence, dysmenorrhea. Pediatrics 6-11 mo: upper respiratory infection (21%), diarrhea (20%), fever (12%), irritability (12%). 12-23 mo: fever (17%), diarrhea (15%), upper respiratory infection (11%).

Safety & Warnings

Contraindications

Hypersensitivity to desloratadine, loratadine, or any excipients/components of the formulation.

Warnings & Precautions

Use with caution in renal and/or hepatic impairment; use with caution in patients with a history of seizures (especially children); discontinue and seek care if hypersensitivity occurs.

Age Restriction

Approved for children ≥6 months (for allergic rhinitis); chronic idiopathic urticaria typically ≥6 months to 1 year depending on local label-use per product leaflet.

Driving Warning

No drowsiness warning; non-sedating antihistamine, though somnolence reported rarely (≈2%)

Drug Interactions

Drug Interactions

Potential increase in desloratadine exposure with ketoconazole, erythromycin, azithromycin, fluoxetine, and cimetidine; additive CNS depression possible with alcohol/other CNS depressants (though desloratadine is usually non-sedating).

Interaction Severity

MINOR: ketoconazole, erythromycin, azithromycin, fluoxetine, cimetidine (may increase desloratadine concentrations without meaningful clinical effects in most patients). MODERATE (clinical caution): alcohol/other CNS depressants due to possible additive sedation in susceptible individuals.

Food Interaction

No restriction.

Alcohol Interaction

Avoid

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

6-11 months: 1 mg (2 ml) once daily; 1-5 years: 1.25 mg (2.5 ml) once daily; 6-11 years: 2.5 mg (5 ml) once daily; ≥12 years: 5 mg (10 ml) once daily

Elderly

Standard adult dosing; no specific dose adjustment required based on age alone

Liver Impairment

Hepatic impairment (especially severe): 5 mg every other day in adults (and reduced-frequency dosing in pediatrics per label).

Storage & Patient Advice

Missed Dose

Take as soon as remembered; skip if near next dose. Do not take two doses at the same time.

Stopping the Medicine

Safe to stop anytime.

Overdose

Symptoms: usually somnolence; may include tachycardia and headache; management: standard measures (consider activated charcoal if appropriate), symptomatic/supportive care; desloratadine is not effectively removed by hemodialysis; seek urgent medical attention.

Patient Counseling

Take once daily with or without food; shake well and measure doses with a calibrated device. Drowsiness is uncommon but possible-avoid driving until you know your response and limit alcohol/CNS depressants. Store below 25°C (per SFDA) and seek medical advice if symptoms persist/worsen or if urticaria is accompanied by angioedema/breathing difficulty.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral H1-receptor antagonist; desloratadine (active metabolite of loratadine) competitively blocks histamine at H1 receptors to reduce allergic symptoms with minimal CNS penetration at recommended doses.

Onset of Action

Within 1 hour.

Duration of Effect

24 hours.

Half-Life

Approximately 27 hours.

Bioavailability

Absolute oral bioavailability is not well established; food has no clinically meaningful effect on exposure.

Metabolism

Extensively metabolized hepatically to 3-hydroxydesloratadine (active), followed by glucuronidation; specific CYP involvement is not fully defined/consistent across sources.

Excretion

Eliminated via both urine and feces (approximately ~41% in urine and ~47% in feces, largely as metabolites).

Protein Binding

Desloratadine: 82-87% (3-hydroxydesloratadine: ~85-89%)

Product Information

Available Dosage Forms

Desloratadine is available (market-dependent) as syrup/oral solution and as oral solid forms including film-coated tablets and orally disintegrating tablets (ODT).

Composition per Dose

Each 1ml of syrup: 0.5mg desloratadine

Generic Availability

Yes

OTC Alternatives

Other OTC second-generation antihistamines: loratadine, cetirizine, levocetirizine, fexofenadine (with age-appropriate formulations such as syrups for children).

Symptom Target

Allergy, Runny Nose

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 14-06-2026