LORADAD 10/MG TAB 10/TAB

Indications

Approved Uses

Symptomatic relief of allergic rhinitis (seasonal and perennial) and chronic idiopathic urticaria (including pruritus).

Dosage & Administration

Dosing by Condition

Adults and children 6 years and over: 1 tablet (10 mg) daily; not more than 1 tablet in 24 hours. Children under 6 years of age: ask a doctor.

Initial Dose

10mg once daily.

Maintenance Dose

10mg once daily.

Maximum Dose

10mg per day in adults

Children's Dosage

Children under 6 years of age: ask a doctor.

Dose Adjustment Notes

Severe hepatic impairment or severe renal impairment (e.g., CrCl <30 mL/min): 10 mg every other day (or 5 mg once daily if available).

Side Effects

Common Side Effects

Headache, fatigue, dry mouth; drowsiness/somnolence can occur (usually uncommon).

Side Effect Frequency

Common (≥1%): headache, somnolence, fatigue; other reported adverse effects such as dry mouth and nausea occur less consistently (often uncommon), while tachycardia/palpitations, rash/alopecia, convulsions, and hypersensitivity reactions are rare.

Safety & Warnings

Contraindications

Hypersensitivity to loratadine or any excipients (including hypersensitivity to desloratadine).

Warnings & Precautions

Use with caution in severe hepatic or renal impairment; may cause rare somnolence-avoid alcohol/other sedatives if affected; stop before allergy skin testing (typically ~48 hours) to avoid false-negative results; consider excipients in patients with rare hereditary galactose intolerance/lactase deficiency/glucose-galactose malabsorption if lactose-containing.

Age Restriction

Not recommended for children under 2 years of age (this 10 mg tablet is generally for ≥6 years; ages 2-5 require 5 mg using an appropriate formulation).

Drug Interactions

Food Interaction

May be taken with or without food; food may delay time to peak concentration but does not require dose adjustment.

Special Populations

Children

Children under 6 years of age: ask a doctor.

Kidney Impairment

Severe renal impairment (CrCl <30 mL/min): 10 mg every other day for adults and children ≥6 years; ages 2-5: 5 mg every other day using an appropriate formulation.

Storage & Patient Advice

Storage Conditions

Store between 20º to 25º C (68º to 77º F).

Stopping the Medicine

Safe to stop anytime.

Overdose

Symptoms: somnolence, tachycardia, headache; management: symptomatic/supportive care, consider activated charcoal if recent ingestion; loratadine is not effectively removed by hemodialysis; seek urgent medical attention.

Patient Counseling

Take 1 tablet (10 mg) once daily, with or without food; may cause drowsiness in some-use caution with driving until you know your response; do not exceed 1 tablet/day; ask a clinician before use if you have severe liver or kidney disease (may need every-other-day dosing); store below 30°C; seek medical advice if symptoms persist or worsen.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Selective peripheral histamine H1-receptor antagonist/inverse agonist that reduces histamine-mediated symptoms (e.g., vasodilation, increased permeability, pruritus).

Onset of Action

1-3 hours.

Duration of Effect

Approximately 24 hours.

Bioavailability

Approximately 40% (oral bioavailability; subject to first-pass metabolism).

Metabolism

Extensive hepatic metabolism primarily via CYP3A4 and CYP2D6 to the active metabolite desloratadine (also called descarboethoxyloratadine).

Product Information

Available Dosage Forms

Tablet (this product).

Composition per Dose

Each tablet: 10mg loratadine

Generic Availability

Yes

OTC Alternatives

Cetirizine, levocetirizine, fexofenadine, chlorpheniramine.

Symptom Target

Allergy, Runny Nose, Itching

Sedating

No

Reviewed by Al Mujtama Pharmacy Medical Review Team. Last reviewed 27-07-2026