LOCOID 0.1% CREAM 30G

Indications

Approved Uses

Relief of inflammatory and pruritic manifestations of corticosteroid‑responsive dermatoses (e.g., atopic dermatitis/eczema, contact dermatitis, seborrhoeic dermatitis, and psoriasis where a topical corticosteroid is appropriate).

Dosage & Administration

Dosing by Condition

Corticosteroid-responsive dermatoses (including atopic dermatitis/eczema, contact dermatitis, psoriasis where appropriate): apply a thin layer to affected areas 1-2 times daily; reduce frequency once improved and limit duration on thin-skin areas (face/flexures) to the shortest possible course.

Initial Dose

Apply a thin layer to the affected area once or twice daily

Maintenance Dose

Once daily application after initial response; use minimum effective frequency

Maximum Dose

No fixed gram maximum in standard guidance; apply a thin layer 1-2 times daily using fingertip-unit guidance, and reassess if not controlled within 2-4 weeks (shorter on face/flexures).

Children's Dosage

Children ≥3 months: Apply thin layer once or twice daily to affected area; limit treatment duration and avoid use on face in young children; safe and effective in children 3 months and older with medical supervision

Dose Adjustment Notes

Use the smallest amount for the shortest duration; once controlled, step down by reducing frequency (e.g., once daily then intermittent/“weekend” use) and maintain with emollients; avoid occlusion unless directed; use extra caution on face, groin, axillae, and in children.

How to Take

For topical use only: apply a thin layer/film to clean, dry affected skin and rub in gently; wash hands before and after (unless treating hands); avoid eyes, mouth and other mucous membranes; do not use occlusive dressings/bandages unless directed; apply to affected areas only.

Side Effects

Common Side Effects

Application-site burning/stinging, itching, irritation, dryness, and erythema; with prolonged/excessive use: skin atrophy, striae, telangiectasia, folliculitis/acneiform eruptions, and perioral dermatitis.

Side Effect Frequency

Common: application-site burning/stinging, pruritus, irritation, dryness/erythema. Uncommon/infrequent: folliculitis, acneiform eruptions, perioral dermatitis, allergic contact dermatitis, hypopigmentation, miliaria, skin atrophy, striae, telangiectasia (risk increases with potency, duration, occlusion, and thin skin). Rare: systemic effects such as HPA-axis suppression/Cushingoid features (especially with large areas, prolonged use, occlusion, or in children) and ocular adverse effects (e.g., glaucoma/cataract) with periocular use.

Safety & Warnings

Contraindications

Hypersensitivity to hydrocortisone butyrate/excipients; untreated bacterial, viral (e.g., herpes simplex, varicella/vaccinia), or fungal skin infections; rosacea; perioral dermatitis; acne vulgaris.

Warnings & Precautions

Avoid eyes/mucosa; avoid occlusion unless supervised; use the smallest amount for the shortest time (extra caution on face/flexures and in children); do not use on untreated infection-treat infection appropriately; discontinue and reassess if irritation/sensitization occurs; taper after prolonged/extensive use.

Age Restriction

Safe and effective in infants ≥3 months; not recommended in infants <3 months; use in children only with medical supervision and for the shortest duration on the smallest area

Driving Warning

Safe

Drug Interactions

Drug Interactions

No clinically significant systemic drug-drug interactions expected with standard topical use; additive systemic corticosteroid effects are possible if used extensively with other topical/systemic corticosteroids or under occlusion.

Interaction Severity

No major drug-drug interactions are expected with standard topical use; clinically relevant additive effects can occur with concurrent corticosteroids (topical or systemic) when used extensively/under occlusion (increased risk of HPA-axis suppression).

Food Interaction

No restriction

Alcohol Interaction

Safe

Special Populations

Pregnancy

Caution

Breastfeeding

Caution

Children

Children ≥3 months: Apply thin layer once or twice daily to affected area; limit treatment duration and avoid use on face in young children; safe and effective in children 3 months and older with medical supervision

Elderly

Standard adult dosing; use with caution as elderly patients may have thinner, more fragile skin increasing risk of atrophy and systemic absorption

Kidney Impairment

No adjustment needed

Storage & Patient Advice

Stopping the Medicine

Stop when control is achieved; if used for prolonged periods, on large areas, or under occlusion, taper by reducing frequency/potency rather than abrupt cessation to reduce rebound dermatitis.

Overdose

Excessive/prolonged use or use on large areas/under occlusion can cause systemic corticosteroid effects (HPA-axis suppression, Cushingoid features, hyperglycemia); manage by reducing/withdrawing gradually and providing supportive care; accidental ingestion usually requires supportive care/medical assessment.

Patient Counseling

Apply a thin layer to the affected area once or twice daily as directed; use the smallest amount for the shortest time needed. Avoid contact with eyes, mouth, and mucous membranes; wash hands after application (unless treating hands). Do not apply to broken/infected skin or use under occlusive dressings/bandages (including diapers) unless advised by a clinician. Avoid prolonged use and large surface areas-especially on the face, groin, or axillae-due to higher risk of skin atrophy and systemic absorption; seek medical advice if not improving within ~2 weeks or if worsening/irritation or signs of infection occur. In pregnancy/breastfeeding, use sparingly on limited areas; avoid applying to the nipple/areola before feeding.

Monitoring Requirements

Short courses generally need no routine labs; clinically monitor response and local adverse effects (atrophy, striae, telangiectasia, perioral dermatitis) and secondary infection; consider HPA-axis suppression risk assessment if prolonged use, large surface area, occlusion, or pediatric use (and monitor growth with long-term/repeated courses in children).

Pharmacology

Onset of Action

Pruritus and erythema often begin improving within 1-3 days, with clearer visible improvement typically within about 1 week (variable by condition and severity).

Duration of Effect

Local anti-inflammatory effect lasts for hours, supporting once- or twice-daily application; clinical control is maintained with regular use and step-down after improvement.

Bioavailability

Percutaneous absorption is generally low with intact skin but is variable and increases with inflammation, damaged skin, use on thin skin (e.g., face/genitals), large surface area, prolonged use, and occlusion.

Product Information

Available Dosage Forms

Cream (this SFDA product: LOCOID CREAM 0.1% topical cream).

Composition per Dose

Each gram of cream: 1 mg hydrocortisone butyrate (0.1%) in a cream base

Generic Availability

Yes

Skin Condition

Eczema, Psoriasis, Dermatitis

Steroid Potency

Moderate

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