LICAN 1% CREAM 30G

Indications

Approved Uses

Interdigital tinea pedis, tinea cruris, tinea corporis

Off-Label Uses

None routinely recommended; do not list onychomycosis or pityriasis (tinea) versicolor as standard off-label uses for luliconazole cream.

Dosage & Administration

Dosing by Condition

Tinea pedis: apply once daily for 2 weeks; Tinea cruris: apply once daily for 1 week; Tinea corporis: apply once daily for 1 week.

Initial Dose

Apply a thin layer to the affected area and approximately 1 inch of surrounding skin once daily

Maintenance Dose

Apply once daily for the prescribed duration (1 week for tinea cruris/corporis, 2 weeks for tinea pedis).

Maximum Dose

Apply a thin layer once daily to affected area(s) (no systemic maximum dose is defined for topical use).

Children's Dosage

Safety and efficacy in pediatric patients have not been established.

Dose Adjustment Notes

No dose adjustment is required (including renal/hepatic impairment) because systemic absorption is minimal with topical use.

How to Take

Clean and dry the affected area before application. Apply a thin layer of cream to the affected skin and approximately 1 inch of surrounding area once daily. Rub in gently. Wash hands after application unless hands are the treated area.

Side Effects

Common Side Effects

Application-site reactions (e.g., burning, stinging, itching/pruritus, erythema/redness, irritation; less commonly contact dermatitis)

Side Effect Frequency

Uncommon (<1%): application-site reactions (e.g., irritation/burning/stinging/pruritus/erythema); post-marketing: contact dermatitis, cellulitis (frequency not known)

Safety & Warnings

Contraindications

Hypersensitivity to luliconazole or any component of the formulation.

Warnings & Precautions

For external (topical) use only; avoid eyes, mouth, and other mucous membranes; not for ophthalmic, oral, or intravaginal use; discontinue and seek advice if significant irritation/sensitization or allergic reaction occurs; use only on indicated skin areas (not nails/scalp unless directed).

Age Restriction

Safety and efficacy in pediatric patients have not been established.

Driving Warning

Safe

Drug Interactions

Drug Interactions

Clinically significant drug interactions are unlikely with topical luliconazole due to minimal systemic absorption; no meaningful in-vivo interaction data exist, and any in-vitro CYP inhibition is of uncertain clinical relevance.

Interaction Severity

No clinically significant drug interactions expected/known with topical luliconazole.

Food Interaction

No restriction

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

Safety and efficacy in pediatric patients have not been established.

Elderly

Standard adult dosing.

Kidney Impairment

No adjustment needed.

Liver Impairment

No adjustment needed.

Storage & Patient Advice

Stopping the Medicine

Complete the full prescribed course; it is appropriate to stop after the recommended duration is finished even if symptoms improved earlier.

Overdose

Topical overdose is unlikely; if accidental ingestion occurs, seek urgent medical advice/poison center and provide supportive care as needed.

Patient Counseling

Apply once daily to clean, dry skin covering the affected area and a small margin around it; wash hands before/after (unless treating hands); avoid eyes/mouth/mucosa; complete the full prescribed course; do not occlude unless directed; stop and seek care if severe irritation or allergic reaction occurs; store below 30°C.

Monitoring Requirements

No routine laboratory monitoring; monitor clinically for local skin irritation/hypersensitivity and treatment response.

Pharmacology

Mechanism of Action

Inhibits fungal lanosterol 14α-demethylase (CYP51), reducing ergosterol synthesis and disrupting fungal cell membrane integrity/function.

Onset of Action

Symptom improvement may begin within a few days (often 2-3 days); assess clinical response by the end of the prescribed course (typically 1-2 weeks).

Duration of Effect

Clinical antifungal effect is maintained with once-daily application throughout the full treatment course; durable cure is assessed after completing therapy (typically 1-2 weeks), rather than as a single fixed hour-based duration.

Half-Life

Unknown / not established for topical luliconazole

Bioavailability

Low systemic absorption after topical application; absolute bioavailability is not well established/clinically relevant.

Metabolism

Unknown / not well characterized for topical luliconazole (systemic metabolism not clinically relevant at topical doses)

Excretion

Unknown / not well characterized for topical luliconazole due to minimal systemic absorption

Protein Binding

>99%

Product Information

Available Dosage Forms

Cream

Composition per Dose

Each gram of cream contains: 10mg luliconazole.

Skin Condition

Fungal

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