JP NERVAN 500/MCG FC TAB 30/FC TAB

Benefits & Uses

Primary Benefit

Supports mood balance, cognitive function, and emotional well-being through saffron's active neuroactive compounds.

Health Claims

Supports mild-to-moderate depressive symptoms; promotes emotional well-being and mood balance; helps relieve symptoms of mild anxiety and stress; supports cognitive function and memory; may improve sleep quality.

Common Deficiency Symptoms

Not applicable - saffron is not an essential nutrient; conditions addressed include low mood, mild anxiety, poor sleep quality, and cognitive decline.

Target Population

Adults experiencing mild-to-moderate mood disturbances, stress, mild anxiety, cognitive decline, or sleep difficulties; adults seeking natural mood and emotional well-being support.

Scientific Evidence Level

Moderate

Onset Timeline

Initial mood and sleep effects may be noticed within 2-4 weeks; significant mood and cognitive benefits are typically observed after 6-8 weeks of consistent daily use.

Usage & Dosage

Suggested Use

Take 1 capsule daily with a meal.

Serving Size

1 capsule

Servings Per Container

30

Recommended Daily Intake

Adults: 28-30mg/day of standardized saffron extract (clinically studied dose range: 28-30mg/day).

Upper Tolerable Limit

Up to 1.5g/day of saffron is considered safe in adults; doses above 5g/day may cause adverse effects; the therapeutic dose of 28-30mg/day is well within the safe range.

Absorption Enhancers

Taking with a meal, particularly one containing some fat, improves absorption of fat-soluble constituents; piperine (black pepper extract) may enhance bioavailability of carotenoid constituents such as crocetin.

Side Effects

Possible Side Effects

Generally well-tolerated at 28-30mg/day; high doses may cause dry mouth, dizziness, nausea, headache, drowsiness, or changes in appetite; rare allergic reactions possible.

Toxicity Risk

Low

Upper Tolerable Limit

Up to 1.5g/day of saffron is considered safe in adults; doses above 5g/day may cause adverse effects; the therapeutic dose of 28-30mg/day is well within the safe range.

Safety & Warnings

Pregnancy Safety

Avoid

Breastfeeding Safety

Consult Doctor

Children Suitability

Not recommended for individuals under 18 years of age.

Interactions

Medication Interactions

May potentiate serotonergic medications (SSRIs, SNRIs, MAOIs) - risk of serotonin syndrome at high doses; may enhance effects of antidepressants; caution with anticoagulants (e.g., warfarin) due to mild antiplatelet activity; may enhance hypotensive and hypoglycemic effects of blood pressure and diabetes medications; may increase sedative effects of CNS depressants.

Supplement Interactions

Caution when combined with St. John's Wort or 5-HTP due to additive serotonergic effects; caution with other supplements having blood-thinning, blood pressure-lowering, or sedative properties.

Special Populations

Target Population

Adults experiencing mild-to-moderate mood disturbances, stress, mild anxiety, cognitive decline, or sleep difficulties; adults seeking natural mood and emotional well-being support.

Children Suitability

Not recommended for individuals under 18 years of age.

Pregnancy Safety

Avoid

Breastfeeding Safety

Consult Doctor

Storage & Patient Advice

SFDA Storage Conditions

store below 25°c

Storage Conditions

Store below 25°C in a cool, dry place. Keep away from direct sunlight and moisture. Keep out of reach of children.

Patient Counseling

Take 1 capsule orally once daily with a meal for consistent absorption. Do not exceed the recommended dose. Consult a healthcare professional before use if taking antidepressants or other serotonergic psychiatric medications (SSRIs, SNRIs, MAOIs), or if diagnosed with bipolar disorder. Use with caution and seek medical advice if taking anticoagulants or antiplatelets, or if a surgical procedure is planned - discontinue at least 2 weeks prior to surgery. Avoid use during pregnancy. Consult a doctor before use if breastfeeding. Not recommended for individuals under 18 years of age. Mood and cognitive effects are gradual - allow at least 6-8 weeks of consistent use before assessing full benefit. Discontinue and seek medical advice if allergic reactions or unusual symptoms occur.

Science & Evidence

Bioavailability Form

Standardized saffron extract in capsule form; crocin is hydrolyzed in the gut to crocetin, which is absorbed into the bloodstream reaching peak concentration in approximately 60-90 minutes; safranal is a volatile aromatic compound with good oral bioavailability when taken with food.

Water or Fat Soluble

Saffron constituents are both water-soluble (crocin) and lipophilic (safranal); crocin is water-soluble; safranal is fat-soluble; crocetin (crocin metabolite) is lipophilic.

Scientific Evidence Level

Moderate

Onset Timeline

Initial mood and sleep effects may be noticed within 2-4 weeks; significant mood and cognitive benefits are typically observed after 6-8 weeks of consistent daily use.

Food Sources

Saffron spice derived from the stigmas of the Crocus sativus flower; therapeutic amounts are not obtainable through dietary use alone.

Product Information

Supplement Type

Herbal

Certification

SFDA registered (Registration No. 208233949); manufactured by Jamjoom Pharmaceuticals Factory Company under GMP standards in Saudi Arabia.

Plant Source

Saffron (Crocus sativus) - dried stigmas of the saffron crocus flower.

Standardized Extract

Standardized saffron extract 28mg - standardized to contain crocin, crocetin, and safranal as primary bioactive constituents (specific percentage standardization not disclosed by manufacturer).