CLARISPRAY MENTHOL NASAL SPRAY 15ML

Indications

Approved Uses

Temporary relief of nasal congestion and sinus pressure due to common cold, hay fever, or other upper respiratory allergies.

Off-Label Uses

Adjunct for epistaxis control (topical vasoconstrictor) and to reduce nasal mucosal bleeding during nasal procedures/surgery.

Dosage & Administration

Dosing by Condition

Nasal congestion (adults and children ≥6 years): 2-3 sprays in each nostril every 10-12 hours (typically morning and bedtime); do not exceed 2 doses in 24 hours; use for no more than 3 consecutive days.

Initial Dose

2 sprays per nostril twice daily (morning and evening).

Maintenance Dose

2 sprays per nostril twice daily (morning and evening).

Maximum Dose

Do not exceed 2 doses in 24 hours; limit use to a maximum of 3 consecutive days.

Children's Dosage

Children 2-6 years: 1 spray per nostril twice daily; Children 6-12 years: 1-2 sprays per nostril twice daily; Not recommended under 2 years.

Dose Adjustment Notes

No dose titration/adjustment is generally required; limit use to a maximum of 3 consecutive days to avoid rebound congestion.

How to Take

Blow nose gently; keep head upright (or slightly forward); insert nozzle into one nostril while occluding the other; spray while breathing in gently through the nose; repeat for the other nostril; avoid spraying into eyes; wipe nozzle and replace cap after use.

How to Prepare

Prime the pump before first use (and if not used for several days) by spraying into the air until a fine mist appears; then use as directed.

Side Effects

Common Side Effects

Transient nasal burning/stinging, dryness/irritation, sneezing; headache may occur; rebound congestion (rhinitis medicamentosa) with use beyond 3 days.

Side Effect Frequency

Oxymetazoline 0.5 mg/mL nasal spray: Common (≥1% to <10%): local nasal irritation/burning/stinging, dryness, sneezing. Uncommon (≥0.1% to <1%): headache. Rare (<0.1%): palpitations/tachycardia, increased blood pressure, insomnia/nervousness, dizziness, nausea. Rebound congestion (rhinitis medicamentosa): frequency not reliably quantifiable; risk increases with use >3 days.

Safety & Warnings

Contraindications

Contraindications: hypersensitivity to oxymetazoline/excipients; concomitant use of MAO inhibitors or within 14 days of stopping; atrophic rhinitis (rhinitis sicca).

Warnings & Precautions

Do not use for more than 3 consecutive days; use with caution in hypertension/heart disease, hyperthyroidism, diabetes, and prostatic hypertrophy/urinary retention; avoid eye contact; do not share the spray to reduce infection transmission.

Age Restriction

Not for use in children under 6 years unless directed by a doctor (for 0.05% oxymetazoline nasal spray).

Driving Warning

Safe

Drug Interactions

Drug Interactions

Key interactions: MAO inhibitors (and within 14 days) - risk of severe hypertension; tricyclic antidepressants - enhanced pressor effects; other sympathomimetics/decongestants - additive cardiovascular/CNS effects; caution with antihypertensives and beta-blockers due to potential BP/HR effects.

Interaction Severity

MAJOR: MAO inhibitors (and within 14 days of stopping) due to risk of hypertensive crisis/marked pressor response. MODERATE: Tricyclic antidepressants and other drugs that increase sympathetic tone (e.g., SNRIs/stimulants/other decongestants) may enhance cardiovascular effects. NOTE: Beta-blockers are not a classic major interaction but cardiovascular effects should be monitored in patients on antihypertensives/cardiac drugs.

Food Interaction

No restriction

Alcohol Interaction

Safe

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Children

Children 2-6 years: 1 spray per nostril twice daily; Children 6-12 years: 1-2 sprays per nostril twice daily; Not recommended under 2 years.

Elderly

Use with caution due to increased risk of cardiovascular effects and urinary retention in elderly males with prostatic hypertrophy; standard adult dosing otherwise

Kidney Impairment

No dose adjustment recommended (not applicable/none) for renal impairment when used intranasally as directed.

Liver Impairment

No dose adjustment recommended (not applicable/none) for hepatic impairment when used intranasally as directed.

Storage & Patient Advice

Storage Conditions

do not store above 30°c

Preparation Instructions

Prime the pump before first use (and if not used for several days) by spraying into the air until a fine mist appears; then use as directed.

Missed Dose

Apply as soon as remembered; skip if near next scheduled dose. Do not double the dose.

Stopping the Medicine

Safe to stop at any time; if used longer than 3 days and rebound congestion occurs, discontinue and consider supportive measures (e.g., saline) and seek medical advice if persistent (an intranasal steroid may be used under clinician guidance).

Overdose

Overdose/accidental ingestion (especially in children) may cause CNS depression or agitation, bradycardia or tachycardia, hypertension or hypotension, respiratory depression, and coma; seek urgent medical attention/poison control and provide supportive care.

Patient Counseling

Use only as directed and for ≤3 consecutive days; do not exceed 2 doses/day (q10-12h). Do not share the bottle; avoid eyes. Seek medical advice before use if you have uncontrolled hypertension, significant heart disease, hyperthyroidism, diabetes, or are taking MAOIs/TCAs; stop and seek care if symptoms persist/worsen after 3 days or if palpitations/severe headache occur. Not recommended for children <6 years unless specifically directed by a clinician.

Monitoring Requirements

No routine monitoring

Pharmacology

Mechanism of Action

Alpha-adrenergic agonist (primarily α1 with some α2 activity) causing vasoconstriction of nasal mucosal vessels, reducing edema and nasal congestion.

Onset of Action

Within 5-10 minutes

Duration of Effect

Up to 12 hours.

Half-Life

Approximately 5-6 hours for intravenous administration; intranasal absorption leads to low systemic exposure.

Bioavailability

Systemic absorption is generally low with recommended intranasal use, but clinically meaningful systemic exposure can occur with overuse, mucosal damage, or accidental ingestion (especially in children).

Metabolism

Limited/partial metabolism with a significant fraction excreted unchanged; detailed metabolic pathways are not well characterized in standard OTC references.

Excretion

For any absorbed drug, elimination is mainly renal with some fecal excretion (exact proportions are not well established in routine references).

Protein Binding

Not well established/variable in standard clinical references (do not rely on a specific percentage for routine counseling).

Product Information

Available Dosage Forms

Nasal spray

Composition per Dose

Each spray (approximately 0.1 mL): 0.05 mg oxymetazoline hydrochloride (0.5 mg/mL); with menthol as excipient

Generic Availability

Yes

OTC Alternatives

Xylometazoline nasal spray, saline nasal spray, pseudoephedrine oral decongestant

Symptom Target

Congestion

Sedating

No

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