CONTRACTUBEX GEL 50G

Indications

Approved Uses

Hypertrophic scars and keloids, and cosmetically disfiguring or movement-restricting scars after surgery, burns, or trauma (including amputations).

Dosage & Administration

Dosing by Condition

New scars (after complete wound closure/suture removal): apply and massage 2-3 times daily for at least 3 months; old/hard hypertrophic scars/keloids: apply 2-3 times daily for several months (often 3-6 months) and may use overnight occlusion if needed.

Maximum Dose

Apply a thin layer to the scar 2-3 times daily (typical maximum: 3 times/day).

Dose Adjustment Notes

No dose adjustment is required in renal or hepatic impairment (topical use with minimal systemic absorption).

How to Take

Apply a thin layer to the scar on intact, fully healed skin and massage gently until absorbed, 2-3 times daily; for old/hard scars, it may be applied under an occlusive dressing overnight if tolerated. Avoid eyes/mucous membranes and do not apply to open wounds.

Side Effects

Common Side Effects

Local application-site reactions: pruritus (itching), erythema/redness, irritation, burning/stinging, and rash.

Safety & Warnings

Contraindications

Hypersensitivity to heparin sodium, onion (Allium cepa) extract, allantoin, or any excipients; do not apply to open wounds/broken skin or mucous membranes.

Drug Interactions

Drug Interactions

No clinically significant drug interactions are expected with topical use on intact skin; avoid combining with other topical irritants/medications on the same area unless advised.

Food Interaction

No known food interactions (not applicable for topical use).

Alcohol Interaction

Safe

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Elderly

Standard adult dosing

Kidney Impairment

No adjustment needed

Storage & Patient Advice

Missed Dose

Apply when remembered and continue the usual schedule; do not apply extra to make up for a missed application.

Monitoring Requirements

No routine monitoring required; monitor for local allergic reactions

Pharmacology

Mechanism of Action

Combination anti-scar action: heparin helps hydrate/soften scar tissue and modulate fibroblast activity; onion extract provides anti-inflammatory/anti-proliferative effects; allantoin supports keratolysis and epithelial remodeling, together improving scar pliability and appearance.

Metabolism

Not clinically relevant/unknown; primarily local action with negligible systemic metabolism expected.

Protein Binding

Not applicable/unknown because systemic absorption is negligible with topical use.

Product Information

Available Dosage Forms

Gel

Composition per Dose

Each 100g of gel contains: 10g of liquid extract from onion, 5000 IU of heparin sodium, and 1g of allantoin.

Generic Availability

No

Skin Condition

Wound Care

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