CLARISPRAY NASAL SPRAY DECONGESTANT ORIGINAL 15ML

Indications

Approved Uses

Temporary relief of nasal congestion due to the common cold, hay fever, or other upper respiratory allergies (allergic rhinitis), and sinus congestion and pressure.

Off-Label Uses

Adjunct for control of anterior epistaxis and to reduce nasal mucosal bleeding during nasal procedures (topical vasoconstrictor use).

Dosage & Administration

Dosing by Condition

Nasal congestion (adults and children ≥6 years): 2-3 sprays in each nostril every 10-12 hours as needed; do not exceed 2 doses in 24 hours; do not use longer than 3 consecutive days.

Dose Adjustment Notes

No routine renal/hepatic dose adjustment is recommended for typical intranasal use; limit use to a maximum of 3 consecutive days to avoid rebound congestion.

How to Take

Blow nose gently before use; keep head upright or slightly forward (do not tilt back); insert nozzle into one nostril while occluding the other; spray while breathing in gently (do not inhale deeply); repeat for other nostril; wipe nozzle and replace cap after use; do not share.

Side Effects

Common Side Effects

Transient nasal burning/stinging, dryness/irritation, sneezing; headache may occur; rebound congestion (rhinitis medicamentosa) with use beyond 3 days.

Safety & Warnings

Contraindications

Contraindications: hypersensitivity to oxymetazoline/excipients; concomitant use of MAO inhibitors or within 14 days of stopping; (often also listed) atrophic/dry rhinitis-while angle-closure glaucoma and hyperthyroidism are typically precautions rather than absolute contraindications.

Warnings & Precautions

Do not use longer than 3 consecutive days; use with caution/seek medical advice in hypertension/heart disease, hyperthyroidism, diabetes, prostatic hypertrophy/urinary retention, and narrow-angle glaucoma; avoid eyes and do not share the spray.

Age Restriction

Not recommended for children under 6 years unless directed by a doctor; use age-appropriate pediatric strength/products for younger children.

Drug Interactions

Drug Interactions

Clinically significant interactions: MAO inhibitors (and within 14 days) and tricyclic antidepressants (increased pressor/sympathomimetic effects); additive effects with other sympathomimetics; caution with antihypertensives/beta-blockers due to potential BP/HR effects.

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Consult Doctor

Elderly

Standard adult dosing; use with caution due to increased risk of cardiovascular effects and prostatic hypertrophy

Kidney Impairment

No dose adjustment recommended/required for renal impairment for intranasal oxymetazoline when used as directed.

Liver Impairment

No dose adjustment recommended/required for hepatic impairment for intranasal oxymetazoline when used as directed.

Storage & Patient Advice

Missed Dose

Usually used as needed; if using on a schedule and a dose is missed, use when remembered unless it is close to the next dose-then skip; do not double doses and do not exceed 2 doses in 24 hours.

Stopping the Medicine

Safe to stop at any time; if used longer than 3 days, rebound congestion (rhinitis medicamentosa) may occur and stopping plus saline/supportive care is advised.

Overdose

Overdose/excess use or ingestion (especially in children) can cause serious CNS and cardiovascular effects (e.g., marked drowsiness/CNS depression, bradycardia, hypotension or hypertension, hypothermia, respiratory depression/coma, or agitation/tachycardia); seek urgent medical care/poison center and treat supportively.

Patient Counseling

Use only in the nose and follow labeled dose (2-3 sprays/nostril every 10-12 hours; max 2 doses/day); do not use longer than 3 consecutive days (rebound congestion risk); avoid sharing the spray; keep out of eyes; seek advice before use if you have hypertension/heart disease, hyperthyroidism, diabetes, or glaucoma, or if taking MAOIs; consult a clinician if symptoms persist/worsen or if significant palpitations, headache, or BP elevation occurs.

Monitoring Requirements

No routine monitoring for most patients; consider monitoring blood pressure/heart rate in patients with cardiovascular disease, hypertension, hyperthyroidism, diabetes, or when overuse is suspected.

Pharmacology

Mechanism of Action

Alpha-adrenergic agonist (primarily alpha-1 with some alpha-2 activity) causing vasoconstriction of nasal mucosal vessels, reducing edema and nasal congestion.

Onset of Action

Within 5-10 minutes.

Duration of Effect

Up to 10-12 hours

Bioavailability

Minimal systemic absorption with recommended intranasal use; systemic exposure increases with excessive dosing, prolonged use, or mucosal damage.

Excretion

Excreted mainly in urine with a smaller portion in feces (systemic absorption is low after intranasal use).

Protein Binding

Not well established/variable in standard clinical references (treat as unknown for practical labeling-level summaries).

Product Information

Available Dosage Forms

Nasal spray, nasal drops, eye drops, topical cream.

Composition per Dose

Each spray (approximately 0.1 mL): 0.05 mg oxymetazoline hydrochloride (equivalent to 0.5 mg/mL concentration)

Generic Availability

Yes

OTC Alternatives

Xylometazoline nasal spray, saline nasal spray, pseudoephedrine oral decongestant

Symptom Target

Congestion

Sedating

No

Legal Disclaimer - Al Mujtama Pharmacy The product information provided is derived from verified pharmaceutical references and is intended for general health education only. It is not a substitute for professional medical advice, diagnosis, or treatment. Al Mujtama Pharmacy assumes no legal or medical liability for: Any therapeutic decision made based on the information displayed without consulting a licensed physician or pharmacist Any discrepancy between the information provided and the product's package insert or SFDA guidelines Any misuse of medication resulting from personal interpretation of the content displayed Important notice: Drug formulations and instructions may vary between production batches. Always rely on the leaflet included inside the product packaging you have, and consult your pharmacist or physician before starting, adjusting, or discontinuing any medication. By using this content, you acknowledge that you have read this disclaimer and agree that Al Mujtama Pharmacy bears no liability arising from reliance on this information as a substitute for direct medical consultation. Your health is a trust - always consult your doctor first.