LAVIE 500 MG 30 TAB

Indications

Approved Uses

Adjunctive therapy for partial-onset seizures in patients aged 1 month and older, myoclonic seizures in patients aged 12 years and older with Juvenile Myoclonic Epilepsy, and primary generalized tonic-clonic seizures in patients aged 6 years and older with Idiopathic Generalized Epilepsy.

Dosage & Administration

Dosing by Condition

Partial-onset seizures (adults): Initial 1000 mg/day (500 mg twice daily); increase by 1000 mg/day every 2 weeks; max 3000 mg/day. Juvenile myoclonic epilepsy (adults/adolescents ≥12 years): Initial 1000 mg/day (500 mg twice daily); increase by 1000 mg/day every 2 weeks; max 3000 mg/day. Primary generalized tonic-clonic seizures (adults): Initial 1000 mg/day (500 mg twice daily); increase by 1000 mg/day every 2 weeks; max 3000 mg/day.

Initial Dose

500 mg twice daily (1000 mg/day)

Maintenance Dose

1000 mg to 3000 mg per day, divided into two doses.

Maximum Dose

3000 mg per day.

Children's Dosage

Children 1 month to <6 months: 7 mg/kg twice daily (max 21 mg/kg twice daily). Children 6 months to <4 years: 10 mg/kg twice daily (max 25 mg/kg twice daily). Children 4 to <12 years: 10 mg/kg twice daily (max 30 mg/kg twice daily). Adolescents 12-17 years (≥50 kg): same as adult dosing

Dose Adjustment Notes

Renal dose adjustment is required based on creatinine clearance; no routine hepatic dose adjustment is needed, but in severe hepatic impairment with concomitant renal impairment, start at ~50% of the usual daily dose (because CrCl may be overestimated). Titration for IR tablets is typically in 500 mg increments.

How to Take

Swallow the film-coated tablet whole with water; may be taken with or without food; for immediate-release levetiracetam tablets, administer in 2 divided doses (typically twice daily) as prescribed.

Safety & Warnings

Contraindications

Hypersensitivity to levetiracetam or other pyrrolidone derivatives.

Warnings & Precautions

Key warnings/precautions: monitor for behavioral/psychiatric changes and suicidality; risk of serious hypersensitivity and severe skin reactions (SJS/TEN/DRESS); adjust dose in renal impairment; avoid abrupt discontinuation; consider monitoring for hematologic abnormalities if clinically indicated.

Age Restriction

Levetiracetam is approved from 1 month of age for certain seizure types; this 500 mg film‑coated tablet is generally appropriate only for patients (typically older children/adolescents/adults) who can safely swallow tablets-use oral solution in infants/young children.

Driving Warning

May Cause Drowsiness

Drug Interactions

Interaction Severity

Clinically most relevant interactions are additive CNS depression with alcohol and other sedatives (caution/avoid alcohol); levetiracetam has minimal clinically significant pharmacokinetic drug-drug interactions (no major CYP effects).

Food Interaction

No clinically significant food restriction; may be taken with or without food (food may delay Tmax but does not meaningfully reduce overall exposure).

Special Populations

Pregnancy

Consult Doctor

Breastfeeding

Caution

Children

Children 1 month to <6 months: 7 mg/kg twice daily (max 21 mg/kg twice daily). Children 6 months to <4 years: 10 mg/kg twice daily (max 25 mg/kg twice daily). Children 4 to <12 years: 10 mg/kg twice daily (max 30 mg/kg twice daily). Adolescents 12-17 years (≥50 kg): same as adult dosing

Elderly

Dose adjustment based on renal function (CrCl); start at lower end of dosing range and titrate carefully; monitor renal function regularly

Kidney Impairment

Dose adjust by creatinine clearance (adult immediate‑release): CrCl >80: 500-1500 mg q12h; CrCl 50-80: 500-1000 mg q12h; CrCl 30-50: 250-750 mg q12h; CrCl <30: 250-500 mg q12h; ESRD on dialysis: 500-1000 mg q24h plus 250-500 mg supplemental after dialysis.

Storage & Patient Advice

Patient Counseling

Take exactly as prescribed (typically twice daily for IR tablets) with or without food; swallow tablets whole; do not stop abruptly without medical advice; may cause dizziness/somnolence-avoid driving/machinery until effects are known; avoid or limit alcohol due to additive CNS effects; report mood/behavior changes or suicidal thoughts promptly; if a dose is missed, take when remembered unless near next dose-do not double.

Pharmacology

Duration of Effect

Immediate-release levetiracetam provides clinical coverage consistent with twice-daily dosing (about 12-hour dosing interval); elimination half-life is ~6-8 hours in adults with normal renal function.

Half-Life

Adults: ~6-8 hours (typical ~7 hours); children generally shorter (~5-7 hours, age-dependent).

Product Information

Available Dosage Forms

Levetiracetam is available as immediate-release tablets/film-coated tablets, oral solution, and IV formulations (solution for injection/infusion or concentrate depending on market); extended-release tablets also exist in some markets but are not the SFDA-listed dosage form for this product.

Composition per Dose

Each film-coated tablet: 500 mg levetiracetam

Generic Availability

Yes

OTC Alternatives

No OTC alternative

Legal Disclaimer - Al Mujtama Pharmacy

The product information provided is derived from verified pharmaceutical references and is intended for general health education only. It is not a substitute for professional medical advice, diagnosis, or treatment.

Al Mujtama Pharmacy assumes no legal or medical liability for:

• Any therapeutic decision made based on the information displayed without consulting a licensed physician or pharmacist
• Any discrepancy between the information provided and the product's package insert or SFDA guidelines
• Any misuse of medication resulting from personal interpretation of the content displayed

Important notice: Drug formulations and instructions may vary between production batches. Always rely on the leaflet included inside the product packaging you have, and consult your pharmacist or physician before starting, adjusting, or discontinuing any medication.

By using this content, you acknowledge that you have read this disclaimer and agree that Al Mujtama Pharmacy bears no liability arising from reliance on this information as a substitute for direct medical consultation.

Your health is a trust - always consult your doctor first.