DUOTRAV EYE DROPS 2.5ML

Indications

Approved Uses

Reduction of elevated intraocular pressure (IOP) in adult patients with open-angle glaucoma or ocular hypertension who are insufficiently responsive to monotherapy with a prostaglandin analogue or a topical beta‑blocker.

Dosage & Administration

Dosing by Condition

Open-angle glaucoma or ocular hypertension: 1 drop in the affected eye(s) once daily (preferably in the evening); do not use more than once daily.

Initial Dose

One drop in the affected eye(s) once daily.

Maintenance Dose

One drop in the affected eye(s) once daily.

Maximum Dose

One drop in the affected eye(s) once daily (do not use more than once daily)

Children's Dosage

Not approved for children under 18 years

How to Take

Ocular use: instill 1 drop into the conjunctival sac of the affected eye(s) once daily (preferably in the evening) at the same time each day. Wash hands; avoid touching the dropper tip to the eye/skin. After instillation, close the eye and perform nasolacrimal occlusion (press inner canthus) for ~2 minutes to reduce systemic absorption. If using other eye drops, separate by at least 5 minutes. Remove contact lenses before use and wait at least 15 minutes before reinsertion.

Side Effects

Common Side Effects

Common: ocular hyperemia (redness), eye irritation/burning/stinging, eye pain/discomfort, pruritus, dry eye, blurred vision; prostaglandin-class effects such as eyelash changes and increased iris/periocular pigmentation can occur.

Special Populations

Children

Not approved for children under 18 years

Storage & Patient Advice

Patient Counseling

Use 1 drop once daily at the same time each day (preferably evening); do not use more than once daily. Wash hands, avoid touching the dropper tip, and perform nasolacrimal occlusion for ~2 minutes. Remove contact lenses and reinsert after ≥15 minutes. Separate from other eye drops by ≥5 minutes. Expect possible redness/irritation and potential permanent iris darkening, eyelash growth, and periocular skin darkening. Seek care for wheeze/shortness of breath, fainting, very slow pulse, or chest pain. Discard the bottle 4 weeks after first opening.

Pharmacology

Mechanism of Action

Travoprost (PGF2α analogue) lowers IOP primarily by increasing aqueous humor outflow (uveoscleral and to some extent trabecular). Timolol (non-selective beta-blocker) lowers IOP by reducing aqueous humor production by the ciliary body.

Duration of Effect

Approximately 24 hours (once-daily IOP control).

Bioavailability

Travoprost is a prodrug rapidly hydrolyzed in the eye to the active acid with very low systemic levels; timolol can be systemically absorbed via conjunctival/nasolacrimal drainage, and nasolacrimal occlusion reduces systemic exposure.

Metabolism

Travoprost is a prodrug hydrolyzed by corneal esterases to the active free acid, then further metabolized (e.g., beta-oxidation and conjugation such as glucuronidation); timolol undergoes hepatic metabolism primarily via CYP2D6.

Product Information

Available Dosage Forms

Eye drops, solution.

Composition per Dose

Each 1ml of solution contains: 40 µg travoprost and 6.8 mg timolol maleate (equivalent to 5 mg timolol).

OTC Alternatives

No OTC alternative

Target Organ

Eye

Preservative Free

No

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